浙江医学2017，Vol.39Issue(12)：964-966,970,后插2,5.DOI:10.12056/j.issn.1006-2785.2017.39.12.2016-1930
肥胖肝癌患者术后3个月血清chemerin、APN和vaspin水平对术后3年病死事件的预测价值
Correlation between serum adipocytokines levels and fatal events in obese patients with hepatocellular carcinoma
摘要
Abstract
Objective To investigate the correlation between serum adipocytokines (chemerin,APN and vaspin) and fatal events in obese patients with hepatocellular carcinoma (HCC).Methods Onehundred and thirty-two obese HCC patients were enrolled in the study,among whom 54 cases died (fatal group) and 78 cases survived (survival group) 3 years after surgery.Serum adipocytokines chemerin,adiponectin (APN) and vaspin levels were measured at 1 and 3 months after surgery,and the correlation of adpocytokines levels with case fatality in 3 years was analyzed.Results The serum levels of chemerin and vaspin were significantly reduced 3 months after surgery,while APN levels were increased (P＜0.05).The levels of chemerin and vaspin in survival group were lower than those in fatal group,while levels of APN were higher (P＜0.05).ROC analysis showed that levels of chemerin at 3 months after surgery (AUC=0.754) had prediction value for 3-year fatality of HCC patients.Regression analysis showed that chemerin level ＞52.6mg/L at 1 month after surgery was independent risk factor for 3-year fatality of HCC patients (OR=2,680,95％CI:1.163-6.178).Conclusion The fluctuation of chemerin after surgery may have prediction value for 3-year fatality of HCC patients.关键词
原发性肝细胞癌/趋化素/脂联素/丝氨酸蛋白酶抑制剂/病死率/肥胖Key words
Hepatic cell cancer/Chemerin/APN/Vaspin/Mortality/Obesity引用本文复制引用
欧宏亮,马莉,陈清锋..肥胖肝癌患者术后3个月血清chemerin、APN和vaspin水平对术后3年病死事件的预测价值[J].浙江医学,2017,39(12):964-966,970,后插2,5.基金项目
宁波市科技计划项目(201501CX-D02007) （201501CX-D02007）
