浙江医学2017，Vol.39Issue(12)：967-970,4.DOI:10.12056/j.issn.1006-2785.2017.39.12.2016-275
高龄男性血清N端骨钙素的独立相关因素探讨
Related factors to serum osteocalcin level in elderly men
摘要
Abstract
Objective To investigate the related factors to serum osteocalcin level in elderly men.Methods A cross-sectional survey was conducted comprising a sample of 1 429 men aged 80 and over.Serum osteocalcin,parathyroid hormone,25-hydroxyvitamin D and sex steroids were measured.The related factors to serum osteocalci level were analyzed with univariate and multivariate regression analyses.Results Multivariate analysis showed that parathyroid hormone(β=0.074,P =0.000),creatinine(β=0.049,P =0.000),cancer (β=2.431,P =0.000),body mass index (β=-0.158,P =0.016),serum sodium (β=0.239,P =0.003),estradiol(β=-0.036,P =0.033),and type 2 diabetes mellitus (β=-1.044,P =0.036) were independent associated factors of serum osteocalcin level in elderly men.Conclusion The probable ways to decrease osteocalcin in men aged 80 and over are to prevent and cure cancer and chronic renal failure,to decrease the concentration of serum parathyroid hormone and serum sodium,and keep a proper body mass index and the concentration of serum estradiol.关键词
骨转换标志物/骨钙素/甲状旁腺素/高龄男性Key words
Bone turnover markers/Osteocalcin/Parathyroid hormone/Elderly men引用本文复制引用
夏清,边平达,应奇峰,李秀央,寿张轩,陈锦平..高龄男性血清N端骨钙素的独立相关因素探讨[J].浙江医学,2017,39(12):967-970,4.基金项目
浙江省医药卫生平台重点资助计划项目(2016ZDA002) （2016ZDA002）
浙江省人民医院优秀青年人员科研启动基金(zry2015C002) （zry2015C002）
