浙江医学2017，Vol.39Issue(12)：976-978,1001,4.DOI:10.12056/j.issn.1006-2785.2017.39.12.2016-1374
恶性肿瘤化疗后肝功能异常的临床特征及其危险因素分析
Clinical features of abnormal liver function in cancer patients with chemotherapy and its related risk factors
摘要
Abstract
Objective To analyze the clinical features of abnormal liver function in cancer patients with chemotherapy and the related risk factors.Methods Three hundred and nine cancer patients receiving chemotherapy were enrolled in the study,among whom abnormal liver function was detected after chemotherapy in 123 cases and the remaining 186 cases had normal liver function.The clinical features of two groups were compared and the risk factors related to abnormal liver function was analyzed with multivariate Logistic regression.Results Most abnormal liver function was detected at the first to forth chemotherapy cycles (96.7％).The chemotherapy was interrupted in 35 cases (28.5％) due to abnormal liver function.Multivariate logistic regression analysis showed that fatty liver disease,hyperlipidemia and hepatic metastasis were the independent risk factors of abnormal liver function after chemotherapy (0R=2.410,1.756 and 2.182,all P＜0.05).The administration of hepatic protectants during chemotherapy was a protecting factor (OR=0.551,P＜0.05).Conclusion The coexistence of fatty liver disease,hyperlipidemia and liver metastasis may increase the risk of abnormal liver function after chemotherapy in cancer patients,and the hepatic protectants may reduce this risk.关键词
恶性肿瘤/化疗/肝功能异常/危险因素Key words
Malignant tumors/Chemotherapy/Abnormal liver function/Risk factors引用本文复制引用
陈群伟,郑晓青,常春阳,单双双,舒琦瑾..恶性肿瘤化疗后肝功能异常的临床特征及其危险因素分析[J].浙江医学,2017,39(12):976-978,1001,4.基金项目
浙江省医坛新秀培养项目(2013-245) （2013-245）
浙江省高等学校中青年学科带头人学术攀登项目(pd2013211) （pd2013211）
