浙江医学2017，Vol.39Issue(12)：993-996,1018,5.DOI:10.12056/j.issn.1006-2785.2017.39.12.2017-395
2型糖尿病患者膳食营养摄入与血清钙、糖代谢之间关系研究
Relationship between dietary nutrients and serum calcium, glycometabolism in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the relationship between the dietary nutrients and serum calcium,glucose metabolism in patients with type 2 diabetes mellitus (T2DM).Methods Two hundred and seven T2DM patients were divided into three groups according to their HbA1C levels,glycemic well-controlled group (40 cases),moderately-controlled group (65 cases) and poorly-controlled group (102 cases).The clinical features,blood glucose levels,the dietary nutrients and energy intake were compared among three groups.The correlation of dietary nutrients with the serum calcium(CsCa) level and biochemical indices of glucose metabolism was analyzed by multiple stepwise regression.Results Compared with moderately and poorly-glycemic controlled groups,the intakes of dietary calcium [(524.14 ± 320.01) mg/L vs (384.68 ± 221.43) mg/L,(481.23 ± 299.65)mg/L,P＜ 0.05],bone phosphorus [(989.03 ± 482.82)g vs (761.79 ± 333.93)g,(852.85 ± 373.15)g,P＜0.05]and protein[(78.87 ± 42.54)g vs (56.85 ± 24.07)g,(66.76 ± 31.33)g,P＜0.05]in well-controlled group were higher,while the levels of parathyroid hormone (PTH) and fasting plasma glucose (FPG) were lower.Multiple stepwise analysis indicated that dietary fat was correlated with CsCa (β=0.203,P＜0.05).Specific alkaline phosphatase(BSAP),FPG,homeostasis model assessment of insulin resistance (HOMA-IR),total cholesterol,1,25-(OH)2D3 were independently correlated with CsCa (β=-0.301,0.490,2.225,-1.800,0.211 and 0.281 respectively,all P＜0.05).Conclusion T2DM patients may lead to loss of the calcium and phosphorus,and insufficient intake of dietary calcium may result to metabolic bone disease.关键词
2型糖尿病/膳食钙/HbA1C/25-羟基维生素DKey words
Type 2 diabetes mellitus/dietary calcium/HbA1C/1,25-(OH)2D3引用本文复制引用
陈爱娇,胡浙芳,冯丽君..2型糖尿病患者膳食营养摄入与血清钙、糖代谢之间关系研究[J].浙江医学,2017,39(12):993-996,1018,5.基金项目
浙江省医药卫生一般研究计划(2015KYB225) （2015KYB225）
