中药材2017，Vol.40Issue(1)：107-110,4.DOI:10.13863/j.issn1001-4454.2017.01.025
头花蓼中木脂素类降糖活性成分的研究
Studies on Lignans of Polygonum capitatum and Their Hypoglycemic Activity
摘要
Abstract
Objective:To study lignans of Polygonum capitatum and their hypoglycemic active constituents.Methods:Lignans were separated and purified by silica gel column chromatography,reversed phase ODS chromatography and Sephadex LH-20.The compounds were identified by their spectral data,and α-amylase inhibitory test were used to evaluate the hypoglycemic activities of the compounds.Results:Seven lignans were isolated from Polygonum capitatum.They were identified as(+)-isolariciresinol(1),(-)-lyoniresinol-2a-O-[6-O-(4-hydroxy-3,5-dimethoxy)-benzoyl]-β-D-glucopyranoside (2),(-)-isolariciresinol-2a-O-β-D-xylopyranoside (3),(+)-5'-methoxyisolariciresinol-9-O-β-D-xylopyranoside (4),(-)-isolariciresinol-3a-O-β-D-glucopyranoside (5),nudiposide (6),lyoniside (7).Conclusion:Compounds 1,2,5,7 are isolated from this plant for the first time,and compounds 2 and 7 are separated from Polygonum genus for the first time.Compounds 1,2,and 4 shows good α-amylase inhibitory activity in vitro,and compound 2 exhibits remarkable α-amylase inhibitory effect.关键词
头花蓼/木脂素类/降糖活性Key words
Polygonum capitatum Buch.-Ham.ex D.Don/Lignans/Hypoglycemic activity分类
医药卫生引用本文复制引用
叶全知,黄光辉,黄豆豆,吕闪闪,吴志军,孙连娜..头花蓼中木脂素类降糖活性成分的研究[J].中药材,2017,40(1):107-110,4.基金项目
国家自然科学基金(81274032) （81274032）
上海中药现代化专项(11DZ1971301) （11DZ1971301）
