中药材2017，Vol.40Issue(1)：171-176,6.DOI:10.13863/j.issn1001-4454.2017.01.039
石榴皮对非酒精性脂肪肝病的基因表达调控数据分析
Gene Regulation Analysis of Effect of the Pomegranate Peel on Non-alcohol Fatty Liver Disease
摘要
Abstract
Objective:To select the different genes expression regulation of rats with non-alcoholic fatty liver disease which were treated with pomegranate peel versus by applying boinformatics analysis tools,and to analyze the possible function of these different expression genes in disease.Methods:The bioinformatics analysis tools as QOE,DAVID and STRING were used for analysis,with the data downloaded from the GEO database of NCBI.Results:Eight different expressed genes were selected,including seven significantly highly expressed genes as CAD,C1QBP,RPL10,RPS7,NHP2,CARM1,LPL;and one lowly expressed gene NR3C1.There were some main biological function of this eight different expressed genes,which including the biosynthesis of pyrimidine nucleotide,the repairing and processing of RNA,the biosynthesis of ribosome and ribonucleoprotein complex,the important matter of cytoplasm and organelles,the relevant genes of lipoprotein biological function,etc.Conclusion:The results shows that the treatment of pomegranate peel for non-alcoholic fatty liver disease can up-regulate the expression of LPL,CARM1,C1QBP,NHP2,RPL10,RPS7,CAD and down-regulate the expression of NR3C1,to promote the hydrolysis of triglycerides,and pomegranate peel can reduce the content of free fatty acid in the blood,and relieve the insulin resistance,strengthen liver cell oxidative stress resistance and maintain the stability of the mitochondrial function,and maintain the normal metabolism of hepatocytes to guarantee the pomegranate peel the non-alcoholic fatty liver disease.关键词
石榴皮/NAFLD/生物信息学分析/分子机制Key words
Pomegranate peel/Non-alcoholic fatty liver disease/Bioinformatics analysis/Molecular mechanism分类
医药卫生引用本文复制引用
林献威,林贯川,马文丽,潘星华..石榴皮对非酒精性脂肪肝病的基因表达调控数据分析[J].中药材,2017,40(1):171-176,6.基金项目
国家自然科学基金(39880032) （39880032）
广东省领军人才基金(C1030925) （C1030925）
