中国现代中药2017，Vol.19Issue(4)：491-495,5.DOI:10.13313/j.issn.1673-4890.2017.4.004
麦冬中具有生物活性的高异黄酮类化学成分研究
Bioactive Homoisoflavonoids from Tuber of Ophiopogon japonicus
摘要
Abstract
Objective:To study the chemical constituents and bioactivities of the tuber of Ophiopogon japonicus.Methods:Single compounds were obtained by comprehensive chromatography technology.Structures were identified by nuclear magnetic resonance(NMR) technology.Results:Compounds isolated from the tuber were identified as 7-O-methyl-3'-hydroxy-3,9-dihydropunctatin (1),(3R)-3,7-dihydroxy-3-(4'-hydroxy-3'-methoxybenzyl) chroman-4-one (2),6-hydroxy-7-O-methyl-3,9-dihydropunctatin (3),7,4'-di-O-methyl-3'-hydroxy-3,9-dihydropunctatin (4),(3R)-3,7-dihydroxy-3-[furan-2'(5H)-one] chroman-4-one(5),(aS)-3,9,10-trihydroxy-7-hydro-6H-dibenz-[b,d] oxocin-7-one (6),(3R)-3-hydroxy-3-(4'-methoxybenzyl)-5,6,7-trimethoxychroman-4-one (7),(3R)-3-hydroxy-3-(4'-hydroxybenzyl)-5,6,7-trimethoxychroman-4-one (8),5-methoxy-6-methyl-7-hydroxy-8-aldehydo-3-(3',4'-methylenedioxybenzyl)chroman-4-one (9),and 5,8,4'-trimethoxy-6-methyl-7,2'-dihydroxy-3-benzylchroman-4-one (10),respectively.Compounds 1,6,and 7 exhibited cytotoxicity against A-549 with IC50 values of 10.1,13.5,8.0 μmol· L-1,respectively.Conclusion:Compounds 1-8 were obtained from the plant for the first time.关键词
麦冬/高异黄酮/细胞毒活性/人肺癌细胞Key words
Ophiopogon japonicus/homoisoflavonoids/cytotoxic activity/A-549引用本文复制引用
姜醒,王兴焱,张春蕾,吕红梅,朱景鑫,王加志,赵敏,苑光军..麦冬中具有生物活性的高异黄酮类化学成分研究[J].中国现代中药,2017,19(4):491-495,5.基金项目
黑龙江省自然基金项目(H201464) （H201464）
