中国现代中药2017，Vol.19Issue(5)：642-647,6.DOI:10.13313/j.issn.1673-4890.2017.5.010
连翘中具有抗菌活性的苯乙醇苷类化学成分研究
Antibacterial Phenylethanoid Glycosides from Fruits of Forsythia suspensa
摘要
Abstract
Objective:To Study on the antibacterial phenylethanoids from the fruits of Forsythia suspensaMethods:The plant materials were extracted with organic solventThe extract was extracted by different polarity organic solvents againCompounds were obtained by comprehensive chromatographyThe structures were identified by NMRResults:Nine compounds were isolated and identified from the fruits of Fsuspensa,including 6'-O-(cis-1,4-dihydroxycyclohexanacetyl)-acteoside (1),4-O-rhamnosyl-7S,8R-7',8'-erythro-sisymbrifolin (2),trichosanthoside A (3),fucatoside B (4),poliumoside B (5),ligupurpuroside J (6),magnoloside F (7),echinacoside (8),and isocrassifolioside (9)Compounds 1,6,8 showed antibacterial activity against Staphylococcus aureus with MICs of 80,160 and 40 μg·mL-1,respectively.Conclusion:Eight phenylethanoide glycosides (1,3-9) and a neolignan (2) were obtained from the plant firstly.关键词
连翘/苯乙醇苷类化合物/抗菌活性Key words
Forsythia suspensa/phenylethanoide glycosides/antibacterial activity引用本文复制引用
姜醒,鲁丽敏,张春蕾,王兴焱,孙琦,王佳天,苑光军..连翘中具有抗菌活性的苯乙醇苷类化学成分研究[J].中国现代中药,2017,19(5):642-647,6.基金项目
黑龙江省自然基金项目(H201464) （H201464）
