中国现代中药2017，Vol.19Issue(5)：679-683,705,6.DOI:10.13313/j.issn.1673-4890.2017.5.017
茯苓不同提取部位对小鼠胃肠运动功能的抑制作用研究
Inhibiting Effects of Different Extracts of Poria on Mice Gastrointestinal Function in vitro and in vivo
摘要
Abstract
Objective:To investigate the relaxing effects among the five extracts of Poriaon gastrointestinal motility in mice and to discover the optimal extractMethods:Tetanic contraction mice small intestine induced by acetyl choline (Ach) was adopted to evaluate the spasmolytic activities among the aqueous extract,25% alcohol extract,50% alcohol extract,75% alcohol extract and 100% alcohol extract of Poria in vitro,and the mean contractile force (MCF) and the contraction frequency (CF) were investigatedThen,the stomach residue rate and the small intestine propulsive rate were evaluated on gastrointestinal motility hyper-function mice induced by neostigmine after orally giving 50% alcohol extract of PoriaResults:All of the aqueous extract,25% alcohol extract,50% alcohol extract,75% alcohol extract and 100% alcohol extract of Poria reversed the small intestine tetanic contraction induced by Ach reducing the MCF with no inhibition on the CFBesides,all of the low,middle and high doses of the 50% alcohol extract of Poria improved the stomach residue rate and reduced the intestine propulsive rate with dose-dependent relationConclusion:All of the five extracts of Poria could significantly antagonized mice small intestine tetanic contraction induced by Ach in vitro,while the 50% alcohol extract of Poria was of the most efficient action,and the 50% alcohol extract of Poria reinstated the gastrointestinal motility of mice induced by neostigmine in vivo.关键词
茯苓/离体小肠/胃排空/小肠推进/提取部位Key words
Poria/isolated small intestinal/gastric emptying/small intestine propulsion,extract fraction引用本文复制引用
肖洪贺,郭周全,郑彧,徐志立,索天娇,杨静娴..茯苓不同提取部位对小鼠胃肠运动功能的抑制作用研究[J].中国现代中药,2017,19(5):679-683,705,6.基金项目
辽宁省自然科学基金项目(201102144) （201102144）
