中医药信息2017，Vol.34Issue(3)：39-44,6.
柴芪汤对代谢综合征大鼠血管损伤预防及治疗的干预机制研究
Protective and Therapeutic Mechanism of Chaiqi Decoction on Vascular Injury of MS Rats
摘要
Abstract
Objective:To observe the effect of Chaiqi decoction on vascular injury of metabolic syndrome rat models and to investigate its mechanism.Methods:The rats were randomly divided into a normal group,a model group,a prevention group and a treatment group.The rat models were established by feeding high fat,high sugar and high salt diet for 8 weeks.The prevention group was given Chaiqi decoction [5.67 g/(kg · d)] from the beginning of modeling,and the treatment group was given Chaiqi decoction since the 8th week.The blood glucose and insulin were detected at 8th and 16th weeks.The levels of sVCAM-1,sICAM-1,TNF-α and IL-6 in serum were measured by ELISA,and the protein expressions of NF-κB in the vessel were detected by Western blot.Results:Compared with that of the normal group,the blood glucose,insulin,insulin resistance index,the levels of sVCAM-1,sICAM-1,TNF-o and IL-6 in serum,the protein expressions of NF-κB in vessel were significantly increased in model group (P ＜ 0.05).All the indexes of the prevention group and treatment group were lower than those of the model group,and the difference was statistically significant (P ＜ 0.05).The indexes of prevention group had more advantages than those of the treatment group.Conclusion:Chaiqi decoction has some active effects on the MS vessel injury by reducing the levels of sVCAM-1,sICAM-1,TNF-o and IL-6 in serum and the protein expressions of NF-κB in vessel.Using Chaiqi decoction at early stage as a prevention can have a better result than as a treatment.关键词
代谢综合征/柴芪汤/血管损伤/预防及治疗Key words
Metabolic syndrome/Chaiqi decoction/Vessel injury/Prevention and treatment分类
医药卫生引用本文复制引用
陈丽如,刘源,张嘉琰,彭龙,张立平..柴芪汤对代谢综合征大鼠血管损伤预防及治疗的干预机制研究[J].中医药信息,2017,34(3):39-44,6.基金项目
国家自然科学基金资助项目(No.81273695) （No.81273695）
高等学校博士学科点专项科研基金项目(No.20130013110016) （No.20130013110016）
