组织工程与重建外科杂志2017，Vol.13Issue(3)：127-130,4.DOI:10.3969/j.issn.1673-0364.2017.03.003
负载纳米磁铁颗粒的PLGA微球的可控制备研究
Preparation and Characterization of Fe3O4 Magnetic Nanopaticles Loaded PLGA Microspheres
陈红 1徐菊美 1赵世成 1岑莲1
作者信息
- 1. 200237 上海市 华东理工大学化工学院
- 折叠
摘要
Abstract
Objective To prepare Fe3O4 magnetic nanopaticles loaded poly(lactic-co-glycolic acid) (PLGA) microspheres using microfluidics, and to characterize this microspheres for future possible applications as targeted drug delivery and MRI tracking. Methods PLGA-Fe3O4 microspheres were prepared by three-phase microfluidic devices. Morphology of microspheres and distribution of Fe3O4 magnetic nanopaticles inside PLGA microspheres were analyzed. Results The PLGA-Fe3O4 microspheres prepared by microfluidic method had uniform particle size distribution and excellent dispersibility. The results of elemental analysis confirmed the presence of Fe, and the results of TEM observation showed that Fe3O4 magnetic nanopaticles were well dispersed inside the microspheres without agglomeration. Conclusion The feasibility of Fe3O4 magnetic nanopaticles loaded PLGA microspheres prepared by microfluidic method is demonstrated. The current study thus provides possibility of using PLGA microspheres for targeted drug delivery and MRI tracking.关键词
聚乳酸-羟基乙酸共聚物微球/纳米磁铁颗粒/微流控法Key words
PLGA microspheres/Fe3O4 magnetic nanopaticles/Microfluidics分类
医药卫生引用本文复制引用
陈红,徐菊美,赵世成,岑莲..负载纳米磁铁颗粒的PLGA微球的可控制备研究[J].组织工程与重建外科杂志,2017,13(3):127-130,4.
