癌变·畸变·突变2017，Vol.29Issue(4)：300-303,4.DOI:10.3969/j.issn.1004-616x.2017.04.011
β-catenin 在肝癌组织中的 表达及对肝癌患者预后的影响
β-catenin expression in hepatocellular carcinoma and its effect onprognosis
摘要
Abstract
OBJECTIVE:To detect the expression of β-catenin and its prognostic significance in hepatocellular carcinoma.METHODS:The expression of β-catenin protein was detected by immunohistochemistry in83cases of resected HCC tissues,26cases of adjacent tissues and5cases of normal liver tissues. The integrated follow-up data were rerospectively analyzed in patients who had undergone radical hepatectomy. The relationships betweenβ-catenin and clincal variables,HCC pathological differentiation and postoperative survival were statistically analyzed.RESULTS:The positive expression rates of β-catenin in the HCC tissues,adjacent tissues and normal liver tissues were 68.67% (57/83)、30.77%(8/26) and 20%(1/5). The positive rate of β-catenin in HCC was significantly higher than that of adjacent tissues and normal liver tissues (P<0.05). The positive expression rates of β-catenin was negatively correlated with pathological differentiation (r=-0.34,P=0.027). In the 83 follow-up data,68 cases were effective. In the first 5 years of follow-up data,and among patients with positive expression of β-catenin,the mean survival time was 11.2 months. Among patients with negative expression of β-catenin,the mean survival time was 26.6 months. Kaplan-Meier survival analysis revealed that patients with negative expression of β-catenin had longer survival time and their prognosis was 2significantly different based on Log-rank test(χ2=15.138,P=0.000).CONCLUSION:Expression of β-catenin was correlated with pathological differentiation in HCC and its high expression predicted poor prognosis.关键词
肝细胞癌/β-catenin/免疫组化/预后Key words
hepatocellular carcinoma/β-catenin/immunohistochemistry/prognosis分类
医药卫生引用本文复制引用
刘德忠,常波,林飞翔,李学东..β-catenin 在肝癌组织中的 表达及对肝癌患者预后的影响[J].癌变·畸变·突变,2017,29(4):300-303,4.基金项目
广东省高水平大学重点学科建设"感染性疾病研究与防治"项目子项目(2016011) （2016011）
