安徽农业科学2017，Vol.45Issue(19)：121-122,2.
变异链球菌UA159细胞壁蛋白的预测和功能分析
Prediction and Functional Analysis of Cell Wall Proteins of Streptococcus mutans UA159
摘要
Abstract
[Objective]The genome sequence of Streptococcus mutans UA159 was studied to predict the proteins anchored in the cell wall by bioinformatics method,which lay the foundation for further study of the pathogenic mechanism of the strain.[Method]The cell wall proteins of S.mutans UA159 were predicted by using Phobius and SignalP 4.0 softwares.The function analysis of cell wall proteins were predicted by using the functional database of Cluster of Orthologous Groups of proteins (COG).[Result]There had 22 cell wall proteins in the genome of S.mutans UA159,in which 12 proteins had LPxTG anchor motif,3 proteins had LysM motif,5 proteins had CW motif,1 protein had GW motif,and 1 protein had PG anchor motif.Functional analysis results showed that 18 proteins of the 22 cell wall proteins had no functional annotations,4 proteins had functional annotations,beta-lactamase protein was related to defensive mechanism function; exo-beta-D-fructosidase protein was related to carbohydrate metabolism and transport; ATP-dependent protease ClpE protein was molecular chaperone protein ,which related to protein post-translational modification and protein folding,cell wall-associatied protein WapA was related to cell wall/membrane biosynthesis.[Conclusion]Most of the cell wall proteins of S.mutans UA159 genome are unknown,and further functional annotations are needed in future study.关键词
变异链球菌/基因组/细胞壁蛋白/功能Key words
Streptococcus mutans/Genome/Cell wall proteins/Function分类
农业科技引用本文复制引用
朱德全,郝莹莹,姚嘉,张跃华,韩诚武,卢伟,栾积毅,刘向东..变异链球菌UA159细胞壁蛋白的预测和功能分析[J].安徽农业科学,2017,45(19):121-122,2.基金项目
黑龙江省教育厅科研项目(2016-KYYWF-0544) （2016-KYYWF-0544）
黑龙江省卫生计生委科研项目(2016-325) （2016-325）
佳木斯大学科技创新团队项目(cxtd-2016-02). （cxtd-2016-02）
