安徽医科大学学报2017，Vol.52Issue(6)：874-878,5.DOI:10.19405/j.cnki.issn1000-1492.2017.06.021
放疗联合p53腺病毒治疗中晚期宫颈癌近期疗效分析
Short-term efficacy of radiotherapy combined with p53 adenovirus in the treatment of advanced cervical cancer
摘要
Abstract
Objective To evaluate the recent clinical effects of intensity modulated radiation therapy(IMRT) combined with recombinant human p53 adenovirus injection in the treatment of locally advanced cervical cancer.Methods Forty-six patients diagnosed with locally advanced cervical carcinoma were divided randomly into the treat-ment group(IMRT combined with p53 gendicine injection) and the control group(single IMRT),with 21 cases in the former group and 25 cases in the other group.Recombinant human p53 adenovirus intratumor injection was performed once a week.The radiotherapy dose and radiotherapy regimen were the same for both groups.After two months of treatment,the efficacy of the treatment was evaluated and the cervical cells were brushed before and after radiotherapy.The number of cells in the cervical cell DNA index≥2.5 was compared between the two groups.Results In the treatment group,complete remission(CR) was in 13 patients(61.9%);partial remission(PR) 6 patients(28.6%),and the effective rate was 90.5%;in the control group,CR was in 7patients(28%),PR 9 patient(36%),and the effectiverate was 64%.The effective rate of treatment group was higher than that of the control group(90.5% vs 64.0%;P<0.05).Analysis of DNA ploidy quantitative after radiotherapy in treatment group and control group was statistically significant(χ2=4.544,P=0.033).Conclusion Imaging and DNA ploidy quantitative analysis conclusion is consistent and showed that recombinant human adenovirus p53 combined with IMRT in the treatment of advanced cervical cancer recent curative effect is better than single IMRT.关键词
宫颈癌/调强放疗/重组人p53腺病毒注射液Key words
cervical cancer/intensity modulated radiation therapy/recombinant human p53 adenovirus分类
医药卫生引用本文复制引用
张冬娟,杨林,陈象逊,汪浩..放疗联合p53腺病毒治疗中晚期宫颈癌近期疗效分析[J].安徽医科大学学报,2017,52(6):874-878,5.基金项目
安徽省卫生计生委中医药科研课题(编号:2016zy33) （编号:2016zy33）
