安徽医科大学学报2017，Vol.52Issue(7)：1078-1080,1084,4.DOI:10.19405/j.cnki.issn1000-1492.2017.07.031
碎裂QRS波在大鼠心肌梗死模型中的价值探讨
The value of fragmentation QRS wave in rat myocardial infarction model
摘要
Abstract
To set up rat myocardial infarction model and to investigate significance of fragmented QRS wave in rat myocardial infarction model.40 rats were divided into sham-operated group and myocardial infarction group, these two sets of rats received surgeries under the same conditions.Myocardial infarction models were induced by opening chest and anterior descending branch of coronary artery deligation for rats.Rats in sham-operated group were only threaded without deligation.Recorded the electrocardiogram(ECG) during 10, 60 min and 4 weeks after the deligation(or threading) and analyzed the change rules of the fragmented QRS waves and Q waves.Tissue samples from myocardial infarction area were collected for HE staining 4 weeks after the surgery.The frequency of fragmented QRS wave in myocardial infarction group was significantly increased during 10, 60 min and at 4 weeks after the operation compared with sham-operated group(P<0.01).Myocardial cells of some models in myocardial infarction group arranged in disorder and showed vacuolation according to results of HE staining.By setting up rat myocardial infarction model, we can draw a conclusion that fragmented QRS wave can be used as a new indicator to diagnose acute myocardial infarction and old myocardial infarction predict the severity of the disease.关键词
碎裂QRS波/急性心肌梗死/陈旧性心肌梗死Key words
fragmented QRS wave/acute myocardial infarction/old myocardial infarction分类
医药卫生引用本文复制引用
叶蕊蕊,张野,马兰..碎裂QRS波在大鼠心肌梗死模型中的价值探讨[J].安徽医科大学学报,2017,52(7):1078-1080,1084,4.基金项目
安徽省高校省级自然科学研究重大项目(编号:KJ2014Z016) （编号:KJ2014Z016）
安徽医科大学校科研基金研究联合资助项目(编号:2015xkj113) （编号:2015xkj113）
