安徽医科大学学报2017，Vol.52Issue(8)：1168-1172,5.DOI:10.19405/j.cnki.issn1000-1492.2017.08.015
基于Array-CGH技术的胚胎植入前遗传学诊断在XYY综合征患者中的应用
PGD for 47,XYY karyotype patientsbased on array comparative genomic hybridization
摘要
Abstract
Objective To evaluate the aneuploidy rates of embryos from men with 47,XYY karyotypes by using the Array-CGH.Methods Five patients with XYY syndrome and the fifteen patients carrying chromosome translocations consulted for infertility and were enrolled.Maternal age,sperm concentration,PR,oocytes,MII oocytes,high quality embryos and aneuploidy of embryos were compared.The t test and the x2 test were used for statistical analysis.Results There were no statistically significant differences in maternal age,sperm concentration,PR,oocytes,MII oocytes,high quality embryos and aneuploidy of embryos between the two groups;a total of 21 embryos in group XYY were biopsied,10(47.62%) of them were autosome aneuploidy embryos and only one embryo(4.80%) has sex chromosome problem.Conclusion Array-CGH is used to screening for aneuploidy of all 24 chromosomes simultaneously,the data from which shows that the aneuploidy rate in embryos in group XYY is as high as that in group translacation,male with a 47,XYY karyotype should be recommended to use PGD to avoid the risk of transferring embryos with potentially aneuploidies.关键词
47,XYY/胚胎非整倍体/Array-CGH/PGDKey words
47,XYY karyotype/aneuploidy of embryos/Array-CGH/PGD分类
医药卫生引用本文复制引用
陈成,贺小进,陈大蔚,吴欢,周平,章志国,曹云霞..基于Array-CGH技术的胚胎植入前遗传学诊断在XYY综合征患者中的应用[J].安徽医科大学学报,2017,52(8):1168-1172,5.基金项目
安徽省科技攻关计划项目(编号:1604a0802077) （编号:1604a0802077）
安徽高校省级自然科学研究项目(编号:KJ2014A114) （编号:KJ2014A114）
