安徽医科大学学报2017，Vol.52Issue(8)：1204-1209,6.DOI:10.19405/j.cnki.issn1000-1492.2017.08.023
循环内皮细胞对冠心病心血管事件的预测价值
The role of circulating endothelial cells in predicting the riskof cardiovascular events in patients with coronary artery disase
摘要
Abstract
Objective To investigate the role of the circulating endothelial cells(CEC)-a direct biomarker of endothelial injury, in evaluating the cardiovascular risk in patients presenting with the acute coronary syndrome(ACS).Methods We studied 110 admitted patients diagnosed as acute coronary artery and 30 healthy controls(HC group).Cardiovascular risk scores were calculated in all ACS patients using two kinds of risk score systems: the thrombolysis in myocardial infarction scoring systems(TIMI) for non-ST-elevation myocardial infarction(NSTEMI)/unstable angina(UA) pectoris, ST-elevation myocardial infarction(STEMI) and the global registry of acute coronary events(GRACE) risk score for all ACS based on patients′ clinical history, symptom, electrocardiogramcharacteristic changes, biochemical outcomes;CEC counting was executed by flow cytometry.Results Compared with HC group, the CEC count of ACS patients was significantly increased, and increased with the severity of disease.There were significant correlation between CEC counts and risk scores(TIMI UA/NSTEMI r=0.47;TIMI STEMI r=0.64;GRACE r=0.61,P<0.05).The area under the receiver-operating characteristic curve(AUC) for the diagnosis of MI(NSTEMI/STEMI) was 0.90(95% CI:0.84~0.94,P<0.01), for the all ACS was 0.89(95% CI:0.82~0.93,P<0.01).Conclusion CEC counts go up with the increasing cardiovascular risk, which is possibly an effective predictive biomarker for clinical cardiovascular events.关键词
循环内皮细胞/心血管事件/心梗/急性冠脉综合征/风险评分Key words
circulating endothelial cells/cardiovascular events/myocardial infarction/acute coronary syndrome/risk score分类
医药卫生引用本文复制引用
潘家义,吴立荣,李伟,李屏,李莎,陈颖,肖良..循环内皮细胞对冠心病心血管事件的预测价值[J].安徽医科大学学报,2017,52(8):1204-1209,6.基金项目
国家留学基金委(编号:201308525105) （编号:201308525105）
贵州医科大学附属医院博士基金资助(编号:C-2012-3) （编号:C-2012-3）
