安徽医科大学学报2017，Vol.52Issue(8)：1244-1246,1250,4.DOI:10.19405/j.cnki.issn1000-1492.2017.08.032
NEDD4基因多态性rs2271289与中国汉族人瘢痕疙瘩表型的相关性研究
Study on association of rs2271289 polymorphism within NEDD4 gene with some clinical phenotypes of keloids in Chinese Han population
摘要
Abstract
Objective To investigate the association of rs2271289 polymorphism with NEDD4 gene and some clinical phenotypes of keloids in Chinese Han population.Methods Based on the results of association study of keloids which were performed by our team.Genotyping data and clinical data of 309 cases and 1 080 controls were selected, Plink1.07 software was for comparing genotype or allele frequency distribution among the groups.Results There was a statistical difference in the distribution of allelic frequencies of rs2271289 between cases and controls(OR=1.62, 95% CI: 1.24~2.10, P=3.28E-04).The cases were stratified from family history, severity and lesion type, there were significant differences between clinical subgroups and controls.Significant associations were found for rs2271289 of NEDD4 with multiple site and severity (P<0.05),However, there was no statistical difference in family history.Conclusion The results indicate that the rs2271289 polymorphism within NEDD4 gene is associated with susceptibility of keloids in Chinese Han population, also it is associated with severity.关键词
瘢痕疙瘩/单核苷酸多态性/表型/NEDD4基因Key words
keloids/single nucleotide polymorphism/phenotype/NEDD4 gene分类
医药卫生引用本文复制引用
赵俊,陆孟珠,张祥,陆闻生..NEDD4基因多态性rs2271289与中国汉族人瘢痕疙瘩表型的相关性研究[J].安徽医科大学学报,2017,52(8):1244-1246,1250,4.基金项目
安徽省自然科学基金(编号:1608085MH175) （编号:1608085MH175）
