吉林大学学报（医学版）2017，Vol.43Issue(4)：739-742,前插3,5.DOI:10.13481/j.1671-587x.20170415
五倍子酸对人胃癌SGC-7901细胞迁移能力的影响
Influence of gallic acid in migration ability of human gastric carcinoma SGC-7901 cells
摘要
Abstract
Objective: To study the influence of gallic acid (GA) on the migration of human gastric carcinoma SGC-7901 cells, and to explore its mechanism.Methods: The human gastric carcinoma SGC-7901 cells were cultured and divided into control group and 3.125, 6.250, 12.500, 25.000, 50.000,100.000 mg·L-1 GA groups. The inhibitory rates of proliferation of SGC-7901 cells in various groups were examined by MTT assay;the migration abilities of SGC-7901 cells in various groups were measured with scratch assay;the expression levels of vascular of endothelial growth factor (VEGF) in various groups were detected by immunocytochemistry.Results: Compared with control group, the inhibitory rates of proliferation of SGC-7901 cells in different doses of GA groups were significantly increased in a dose-dependent manner(F=59.451,P<0.01).Compared with control group, the wound healing rates in different doses of GA groups were significantly decreased (P<0.01).Compared with control group, the expression levels of VEGF protein in 12.500 and 25.000 mg· L-1 GA groups were decreased (P<0.05).Conclusion: GA could inhibit the proliferation and migration of SGC-7901 cells through down-regulating the expression levels of VEGF protein.关键词
五倍子酸/SGC-7901细胞/细胞迁移/血管内皮生长因子Key words
gallic acid/SGC-7901 cells/cell migration/vascular endothelial growth factor分类
医药卫生引用本文复制引用
王丽萍,冯若,邹立洋,丁一..五倍子酸对人胃癌SGC-7901细胞迁移能力的影响[J].吉林大学学报（医学版）,2017,43(4):739-742,前插3,5.基金项目
河南省科技厅科技攻关项目资助课题(122102310233) （122102310233）
河南省卫计委科研项目资助课题(200803061) （200803061）
