吉林大学学报（医学版）2017，Vol.43Issue(4)：770-775,前插4,7.DOI:10.13481/j.1671-587x.20170421
β-tubulin Ⅲ在结肠腺癌组织中的表达及其临床意义
Expression of β-tubulin Ⅲ in colon adenocarcinoma tissue and its clinical significance
摘要
Abstract
Objective:To detect the expression and clinical significance of β-tubulin Ⅲ in cancer tissue of the patients with colon adenocarcinoma,and to explore its clinical significance.Methods:A total of 111 colon adenocarcinoma tissue samples were obtained.According to the location of β-tubulin Ⅲ positive cells, all patients were divided into front group (n=72) and non-front group (n=39).The positive expression rate of β-tubulin Ⅲ in the patients with colon adenocarcinoma was detected with immunohistochemistry.The correlations among the expression of β-tubulin Ⅲ and gender,age,tumor differentiation, clinical stage, lymph node metastasis, recurrence and death were analyzed.Results: The expression levels of β-tubulin Ⅲ had no significant differences between the patients with different gerder,age,lymph node metastasis,clinical stages,death and recurrence.The positive expression rates of β-tubulin in cancer tissue of the patients had significant difference between front and non-front groups (χ2=8.76, P=0.01).Lowly-to-moderately differentiated tissue was more common in front group, and highly-differentiated tissue was more common in non-front group(χ2=6.88, P=0.03).There were significant differences in the expression levels of β-tubulin Ⅲ between cancer tissues with different differentiation degrees (χ2=5.74, P=0.04).In non-front group, lymph node metastasis was closely correlated with the expression of β-tubulin Ⅲ (χ2=6.02,P=0.05).The results of immunohistochemical staining showed that the β-tubulin Ⅲ positive-expressing cells were colored brown-yellow.The number of cells with positive β-tubulin Ⅲ expression was significantly increased in highly differentiated tissue compared with low-differentiated tissue.Conclusion:The expression of β-tubulin Ⅲ is closely related to tumor differentiation in colon adenocarcinoma tissue.The highly differentiated colon adenocarcinoma tissue is more common in non-front group in which the expression of β-tubulin Ⅲ is related to lymph node metastasis.关键词
结肠肿瘤/腺癌/β-tubulinⅢ/免疫组织化学Key words
colonic neoplasms/adenocarcinoma/Β-tubulin Ⅲ/immunohistochemistry分类
医药卫生引用本文复制引用
石俊忠,庄建彬,张传山,刘贤明,孔大陆..β-tubulin Ⅲ在结肠腺癌组织中的表达及其临床意义[J].吉林大学学报（医学版）,2017,43(4):770-775,前插4,7.基金项目
天津市卫计委重点攻关项目资助课题(15KG116) （15KG116）
