川北医学院学报2017，Vol.32Issue(3)：332-335,4.DOI:10.3969/j.issn.1005-3697.2017.03.005
高频振荡通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征
High frequency oscillatory ventilation combined with pulmonary surfactant in treatment of neonatal respiratory distress syndrome
摘要
Abstract
Objective:To study the effectiveness of pulmonary surfactant (PS) combined with high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in neonatal respiratory distress syndrome (NRDS).Methods:A total of 60 neonates diagnosed with NRDS between January 2014 and December 2015 in the NICU of Xiangyang Central Hospital.The neonates were randomly divided into two groups:HFOV group (n=28) and CMV group (n=32),based on their gestational age and birth weight.HFOV group was given high frequency oscillatory ventilation and CMV group was given normal frequency oscillatory ventilation,all combined with pulmonary surfactant (PS).Compare oxygen partial pressure (PaO2),partial pressure of carbon dioxide (PaCO2) and oxygenation index (OI) before and after 2 h,12 h,24 h of treatment,at the same time the mechanical ventilation time and occurrence rates of complicantions such as lung leakage,pneumorrhagia and bronchopulmonary dysplasia were compared.Results:After treatment 2 h,12 h and 24 h,in two groups OI and PaCO2 decreased,at the same time PaO2 increased.But the effects of HFOV group were more obvious,with statistical significance(P<0.05).While,mechanical ventilation time was obviously shorter than CMV group (P<0.05),and occurrence of lung leakage ratio is lower than CMV group (P<0.05),but BPD and pneumorrhagia in the two groups had no statistically significance (P>0.05).Conclusion:In treatment of NRDS,HFOV+PS is more effective than CMV+PS to improve oxygenation,reduce lung injury.关键词
高频振荡通气/新生儿呼吸窘迫综合征/肺表面活性物质Key words
High frequency oscillatory ventilation/Neonatal respiratory distress syndrome/Pulmonary surfactant分类
医药卫生引用本文复制引用
黄方,陈霞,饶绘..高频振荡通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征[J].川北医学院学报,2017,32(3):332-335,4.基金项目
湖北省自然科学基金(hb281823) （hb281823）
