磁共振成像2017，Vol.8Issue(7)：514-518,5.DOI:10.12015/issn.1674-8034.2017.07.007
腰椎终板Modic改变与椎间盘退变的相关性的定量MRI研究
Quantitative MR imaging study of association between lumbar vertebral endplate Modic changes and intervertebral disc degeneration
摘要
Abstract
Objective: To investigate the relationship between vertebral endplate Modical changes and adjacent intervertebral disc degeneration. Materials and Methods: Lumbar structure and quantitative MR images of 66 patients were retrospectively analyzed. Disc degeneration was semi-quantitatively assessed using Pfirrmann grading system and quantitatively assessed using T2 and T2* values. Association between Pfirrmann scores, T2 and T2* values of intervertebral discs with adjacent endplate Modic changes was analyzed. Results: Nineteen intervertebral discs with adjacent endplate Modic changes were detected in fourteen patients (14/66, 21.2%), which included 2 discs with Modic type 1 changes and 17 discs with type 2 changes. Pfirrmann scores of the discs adjacent to normal endplates, Modic type 1 endplates and Modic type 2 endplates were 2.40±0.96、4±1.41 and 4.12±1.27, respectively. T2 values were (95.38±51.88) ms, (70.50±36.06) ms and (58.65± 38.47) ms. T2* values were (34.43±19.16) ms, (24.00±1.41) ms and (28.65±23.00) ms. The differences of disc Pfirrmann scores, T2 and T2* values among different endplate changes were statistical significant with P values of 0.000, 0.000 and 0.023, respectively. Comparing to discs adjacent to normal endplates, discs adjacent to Modic type 2 endplates had severe degeneration with increased Pfirrmann scores and decreased T2 and T2* values. The differences were statistical significant (P values were 0.000, 0.000 and 0.006, respectively). Conclusions: Modic changes of vertebral endplate are associated with adjacent intervertebral disc degeneration. Both of them should be regarded as a facet of the "whole-organ" pathologic conditions in the procession of spinal degeneration.关键词
椎间盘退化/腰椎/磁共振成像Key words
Intervertebral disc degeneration/Lumbar vertebrae/Magnetic resonance imaging分类
医药卫生引用本文复制引用
龚静山,梅东东,朱进,周阳泱..腰椎终板Modic改变与椎间盘退变的相关性的定量MRI研究[J].磁共振成像,2017,8(7):514-518,5.基金项目
深 圳 市 科 技 计 划 项 目 ( 编 号 :JCYJ2014041622811967) This work was supported by Shenzhen Science &Technology Program (No. JCYJ2014041622811967). （ 编 号 :JCYJ2014041622811967）
