重庆医学2017，Vol.46Issue(19)：2608-2611,4.DOI:10.3969/j.issn.1671-8348.2017.19.005
点地梅提取物对大鼠股骨创伤愈合的影响
Effects of Androsace umbellata extract on bone wound healing in rats
摘要
Abstract
Objective To study the effects of Androsace umbellata extract on bone wound healing in rats.Methods A total of 32 rats were selected,and the rat femur bone trauma model was established.The Androsace umbellata was administrated to rats in treatment groups (including high-dose Androsace umbellata group and low-dose Androsace umbellata group,8 rats in each group)continuously for 10 days,while rats in the fake operation control group (8 rats)and bone trauma model group (8 rats) were treated with corresponding volume of solvent by body weight.The growth of body weight and wound healing of rats were recorded.The serum levels of calcium and phosphorus,activity of alkaline phosphatase (ALP),bone density and bone biomechanics were examined.The X-ray photograph was carried out to observe the effects of Androsace umbellata on bone wound healing,Results Compared with the bone trauma model group,serum levels of calcium and phosphorus,calcium-phosphorus product and activity of ALP were significantly increased in treatment groups,there were statistically significant differences (P＜0.05).Compared with the bone trauma model group,bone density of trauma place in the high-dose Androsace umbellata group was significantly decreased (P＜0.05),bending energy in the low-dose Androsace umbellata group was increased (P＜0.05),while no statistically significant difference was found in the other skeletal biomechanical properties (P＞0.05).The results of X-ray films indicated that the treatment groups shown better effects on bone wound healing compared with the bone trauma model group.Conclusion Androsace umbellata extract could effectively promote bone wound healing in rats.关键词
点地梅/大鼠/股骨/骨创伤Key words
Androsace umbellata/rats/femur/bone trauma分类
医药卫生引用本文复制引用
黄景,何开家,苏华,何飞,唐毓凡,曾先彪,邱宏聪,韦宝伟,韦桂宁..点地梅提取物对大鼠股骨创伤愈合的影响[J].重庆医学,2017,46(19):2608-2611,4.基金项目
广西科学研究与技术开发计划项目重大专项(桂科重14124002-4) （桂科重14124002-4）
广西壮族自治区卫生厅中医药科技专项(GZZJ13-15、GZZJ14-10) （GZZJ13-15、GZZJ14-10）
广西自然科学基金项目(2011 GXNSFA018258). （2011 GXNSFA018258）
