重庆医学2017，Vol.46Issue(19)：2621-2623,3.DOI:10.3969/j.issn.1671-8348.2017.19.009
妊娠期肝内胆汁淤积症血清总胆汁酸与新生儿肺损伤程度的相关性
Study on maternal serum total bile acids in intrahepatic cholestasis of pregnancy on neonatal lung injury
摘要
Abstract
Objective To explore the correlation between maternal serum total bile acid (TBA) of pregnant women with intrahepatic cholestasis of pregnancy (ICP) and varying degrees of neonatal lung injury.Methods A total of 52 cases of pregnant women with ICP and their corresponding newborns were enrolled into the ICP group from March 2014 to December 2015 in the People's Hospital of Shapingba District.Other 52 cases of pregnant women received cesarean delivery whose gestational age and birth weight of newborns were close to the ICP group and their corresponding newborns were selected as the control group.The conditions of neonatal lung injury were recorded,and the correlations of maternal serum level of TBA and exposure time of high serum level of TBA to degrees of lung injury were analyzed as well.Results The incidence rate of neonatal lung injury in the ICP group (67.3 ％) was higher than that in the control group (17.3 ％),there was statistically significant difference (P＜0.05).The degree of lung injury was positively correlated with maternal serum level of TBA and exposure time of high serum level of TBA (r=0.687,P=0.000;r=0.523,P=0.001).Conclusion The probability of neonatal lung injury of corresponding pregnant women with ICP is significantly increased,and the extent of lung injury is positively correlated with concentration of maternal serum TBA and exposure time of high serum level of TBA.关键词
呼吸窘迫综合征,新生儿/胆汁淤积,肝内/总胆汁酸/暴露时间Key words
respiratory distress syndrome, newborn/cholestasis, intrahepatic/total bile acid/exposure time分类
医药卫生引用本文复制引用
文香,胡章雪,廖莉..妊娠期肝内胆汁淤积症血清总胆汁酸与新生儿肺损伤程度的相关性[J].重庆医学,2017,46(19):2621-2623,3.基金项目
重庆市卫生局医学科研项目(2013-2-200). （2013-2-200）
