动物营养学报2017，Vol.29Issue(7)：2252-2260,9.DOI:10.3969/j.issn.1006-267x.2017.07.006
单胃动物肠道菌群与宿主肠道免疫系统的互作关系及可能机制
Interaction between Intestinal Microflora and Intestinal Immune System of Host and Its Possible Mechanisms in Monogastric Animals
摘要
Abstract
The intestinal tract of monogastirc animals harbors large amount of microorganisms with complex species.The intestinal microbes and their metabolites coevolve with the intestinal immune system of host.These microbes and their metabolites play an important role in maintaining hosts' intestinal homeostasis.Accumulating evidences indicated that normal microflora could promote the development of immune system and regulate the maintaining of immunologic function of host, as well as co-resist the proliferation and invasion of various pathogens.In contrast, the intestinal immune system of host exhibits restrictive and regulatory roles to symbiotic microflora, for examples, immune tolerance to normal flora, or immunological rejection to pathogens.The breakdown of this homeostasis causes the occurrence of gastrointestinal diseases of host.Here, we reviewed the interaction between intestinal microflora and the intestinal immune system of host.Based on the results of existing studies, the possible mechanisms were also systemically summarized.关键词
单胃动物/肠道菌群/肠道免疫系统/免疫细胞/潜在机制Key words
monogastric animals/intestinal microflora/intestinal immune system/immunocytes/underlying mechanism分类
农业科技引用本文复制引用
李佳彦,罗玉衡,陈代文,余冰,何军,虞洁,毛湘冰,罗钧秋,郑萍,黄志清..单胃动物肠道菌群与宿主肠道免疫系统的互作关系及可能机制[J].动物营养学报,2017,29(7):2252-2260,9.基金项目
国家自然科学基金项目(3167131062) （3167131062）
