南方医科大学学报2017，Vol.37Issue(7)：902-906,5.DOI:10.3969/j.issn.1673-4254.2017.07.08
辅助生殖技术中发生枯萎卵的影响因素
Blighted ovum in subfertile patients undergoing assisted reproductive technology
摘要
Abstract
Objective To explore the incidence and risk factors of blighted ovum in subfertile patients undergoing assisted reproductive technology (ART). Methods This retrospective analysis was conducted among 2378 patients who were pregnant following embryo transfer at our center from January, 2012 to December, 2015, including cases of early pregnancy losses and simultaneous live births. The cases with early pregnancy losses were divided into embryonic pregnancy and blighted ovum groups based on the presence or absence of an embryonic pole before dilation and curettage. The clinical data of the 3 groups were analyzed for comparisons of the maternal age, paternal age, BMI, AFC, basal FSH, bFSH/bLH, duration of infertility, Gn dosage, Gn days, serum estradiol on the day of HCG administration, endometrium thickness, number of oocyte retrieved, proportion of high-quality embryos transferred, serum β-HCG value on the 10th to 14th days of embryo transfer, infertility type and miscarriage times. The incidences of blighted ovum were compared between cases with different cycles, embryo stages, infertile factors and methods of fertilization. Results Maternal age and paternal age, BMI, duration of infertility, infertility type and miscarriage times differed significantly between cases with blighted ovum and those with live births. Serum β-HCG level was the lowest in blighted ovum group followed by embryonic pregnancy group and then by live birth group. Blastocyst transfer was associated with a significantly higher incidence of blighted ovum as compared with cleavage embryo transfer (11.6%vs 5.6%, P=0.000). No significant difference was found in the other parameters among the 3 groups (P>0.05). Adjusted logistic regression analysis showed that maternal age,β-HCG level and blastocyst transfer were risk factors of blighted ovum. Conclusion Advanced maternal age, low β-HCG level and blastocyst transfer may increase the risk of blighted ovum possibly in association with gene imprinting errors during the early stage of embryo development.关键词
辅助生殖技术/枯萎卵/基因印记Key words
assisted reproductive technology/blighted ovum/gene imprinting引用本文复制引用
聂庆文,华芮,周瑶,李红,余艳红..辅助生殖技术中发生枯萎卵的影响因素[J].南方医科大学学报,2017,37(7):902-906,5.基金项目
国家科技支撑计划项目(2013BAI12B01-7) （2013BAI12B01-7）
广东省自然科学基金(1414050001657) Supported by National Plan for Science and Technology Research (2013BAI12B01-7). （1414050001657）
