南方医科大学学报2017，Vol.37Issue(7)：929-932,4.DOI:10.3969/j.issn.1673-4254.2017.07.13
新鲜周期全胚冷冻策略不影响体外受精-胚胎移植妊娠及产科结局:≤35岁患者的疗效分析
Pregnancy and obstetric outcomes of fresh embryo transfer versus frozen-thawed embryo transfer in women below 35 years of age
孙玲 1陈志恒 1尹敏娜 1邓宇1
作者信息
- 1. 广州市妇女儿童医疗中心生殖医学中心,广东 广州 510623
- 折叠
摘要
Abstract
Objective To compare the obstetric and perinatal outcomes between fresh embryo transfer (ET) and frozen-thawed ET (the "freeze-all" strategy) and evaluate the benefits of the "freeze-all" embryo strategy for young patients. Methods We reviewed a total of 2091 ET cycles performed between January, 2011 and December, 2015 in women aged 20-35 years, including 1295 fresh ET cycles and 796 frozen-thawed ET cycles. The demographic characteristics, ovarian stimulation syndrome, clinical pregnancy rates, live birth rate and the obstetric outcomes (gestational age, preterm delivery rate and mean birth weight) were compared between the two groups. Results The mean age of the patients receiving frozen-thawed ET cycles had a significantly younger age than those having fresh ET cycles (29.5 vs 30.2 years, P<0.05); the patients undergoing frozen-thawed ET cycles also had significantly higher estradiol level on the day of trigger (12973 pmol/L vs 8673 pmol/L ) and a greater oocyte number retrieved (12.7 vs 8.7). The incidence of severe ovarian hyperstimulation syndrome was significantly lower in patients with frozen ET than those with fresh ET (P<0.05). No significant differences were found in the pregnancy rate (59.5%vs 56.0%;P>0.05), live birth rate (50.3%vs 47.0%;P>0.05), mean birth weight or gestational age between the two groups. Conclusions The freeze-all policy produces similar pregnancy and obstetric outcomes with those of fresh ET. Our results support the hypothesis that the freeze-all strategy help to prevent OHSS with a good pregnancy rate.关键词
全胚冷冻/卵巢过度刺激综合征/妊娠结局/产科结局Key words
freeze-all strategy/pregnancy outcomes/obstetric outcomes/ovarian hyperstimulation syndrome引用本文复制引用
孙玲,陈志恒,尹敏娜,邓宇..新鲜周期全胚冷冻策略不影响体外受精-胚胎移植妊娠及产科结局:≤35岁患者的疗效分析[J].南方医科大学学报,2017,37(7):929-932,4.
