南方医科大学学报2017，Vol.37Issue(7)：938-942,5.DOI:10.3969/j.issn.1673-4254.2017.07.15
apoB与LDL-C评估冠心病风险的临床价值比较
Clinical value of apolipoprotein B versus low-density lipoprotein cholesterol in assessing risks of coronary artery disease
摘要
Abstract
Objective To compare the value of apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) in assessing the risk of coronary heart disease in patients with inconsistent apoB and LDL-C levels. Methods In a total of 603 patients undergoing coronary angiography, apoB and LDL-C levels were categorized into high and low levels relative to the median levels of apoB and LDL-C, based on which the patients were divided into 4 groups with low apoB/low LDL-C, low apoB/ high LDL-C, high apoB/ low LDL-C, or high apoB/high LDL-C. According to the results of coronary angiography, we evaluated the number of coronary artery branches with lesions and the severity of coronary artery stenosis in the 4 groups to assess the correlation of apoB and LDL-C with cardiovascular risks. Results We found significant differences in the number of coronary artery branches with lesions and the severity of coronary artery stenosis among the 4 groups (P<0.05). The number of coronary artery branches involved and the severity of stenosis differed significantly between patients with consistently high and low apoB/LDL-C levels (P<0.005). Compared with those with low apoB/low LDL-C levels, the patients with high apoB/low LDL-C levels showed a significantly greater number of coronary artery branches with lesions (P=0.017) and more severe stenosis (P=0.034), but such differences were not found in patients with low apoB/ high LDL-C levels. Pearson correlation analysis identified LDL-C and apoB as the risk factors for cardiovascular disease with areas under the ROC curve of 0.579 (P=0.014) and 0.589 (P=0.006), respectively. Conclusions In patients with inconsistent levels of apoB and LDL-C, apoB and LDL-C levels are both risk factors of coronary heart disease in close relation with the disease severity. LDL-C and apoB are comparable for their important values in predicting the risk of coronary heart disease.关键词
载脂蛋白B/低密度脂蛋白胆固醇/冠心病冠状动脉造影/冠状动脉狭窄程度/冠状动脉病变支数Key words
apolipoprotein B/low-density lipoprotein cholesterol/coronary heart disease/coronary angiography/coronary artery lesions/coronary artery stenosis引用本文复制引用
陈思,赵金珍,胡晶,郭志刚..apoB与LDL-C评估冠心病风险的临床价值比较[J].南方医科大学学报,2017,37(7):938-942,5.基金项目
国家自然科学基金(81370380) （81370380）
广东省教育厅省级重大项目(2014KZDXM020) （2014KZDXM020）
广州市科技计划科学研究专项一般项目(201510010090) （201510010090）
南方医科大学临床研究培育项目(LC2016PY002) Supported by National Natural Science Foundation of China (81370380). （LC2016PY002）
