南方医科大学学报2017，Vol.37Issue(7)：943-946,961,5.DOI:10.3969/j.issn.1673-4254.2017.07.16
高尿酸血症与风湿性主动脉瓣置换后不良事件的关系:>40岁患者分析
Relationship between hyperuricemia and adverse events in patients aged 40 years or older receiving rheumatic aortic valve replacement
吴樱 1柯组辉 1黄英杰 1黄洁棱 1余丹青 1魏学标 1陈晓兰1
作者信息
- 1. 广东省心血管病研究所心内科//广东省冠心病防治研究重点实验室//广东省人民医院//广东省医学科学院,广东 广州 510080
- 折叠
摘要
Abstract
Objective To explore the prognostic value of hyperuricemia for adverse events in patients >40 years old receiving valve replacement surgery for rheumatic aortic valve disease. Methods Consecutive middle-aged and elderly patients receiving aortic valve replacement surgery for rheumatic aortic valve disease between March, 2009 and July, 2013 were recruited in this study. The patients were divided into hyperuricemic group and normouricemic group based on their serum levels of uric acid, and the clinical data and adverse events within 1 year after the surgery were compared between the 2 groups. Results A total of 632 consecutive patients were recruited, including 381 patients with hyperuricemia and 251 with normouricemia. The in-hospital mortality rate was significantly higher in hyperuricemic group than in normouricemic group (7.6% vs 2.0%, P=0.002). Serum uric acid levels were negatively correlated with eGFR (r=-0.421, P<0.001) and positively correlated with C-reactive protein level (r=0.093, P=0.025). Multivariate analysis showed that hyperuricemia was independently associated with the in-hospital mortality (OR=3.07, 95%CI:1.13-8.37, P=0.028) and mortality at 1 year after the surgery (HR=3.14, 95%CI: 1.30-7.62, P=0.011) after adjusting for potential risk factors including age, NYHA III-IV and postoperative acute kidney injury (AKI). Kaplan-Meier analysis showed that the cumulative rate of 1-year mortality after surgery was significantly higher in patients with hyperuricemia (Log-rank=11.73, P=0.001). Conclusion Hyperuricemia is a predictor of in-hospital and one-year mortality in middle-aged and elderly patients following aortic valve replacement surgery for rheumatic aortic valve disease.关键词
高尿酸血症/风湿性心脏病/瓣膜置换手术Key words
hyperuricemia/rheumatic heart disease/valve replacement引用本文复制引用
吴樱,柯组辉,黄英杰,黄洁棱,余丹青,魏学标,陈晓兰..高尿酸血症与风湿性主动脉瓣置换后不良事件的关系:>40岁患者分析[J].南方医科大学学报,2017,37(7):943-946,961,5.
