南方医科大学学报2017，Vol.37Issue(7)：952-956,5.DOI:10.3969/j.issn.1673-4254.2017.07.18
血管生成抑制蛋白1和结肠癌转移相关蛋白-1在肺鳞状细胞癌中的表达及其临床意义
Expression of vasohibin-1 and MACC1 in lung squamous cell carcinoma and their clinicopathological significance
摘要
Abstract
Objective To investigate the expressions of vasohibin-1 and MACC1 in lung squamous cell carcinoma (LSCC) and their associations with the clinicopathological characteristics of the patients. Methods The expressions of vasohibin-1 and MACC1 proteins were examined with immunohistochemistry in 160 LSCC tissues and 80 normal lung tissues. Results The positivity rates of vasohibin-1 and MACC1 proteins were 59.4% and 11.3% in LSCC tissues, respectively, which were significantly higher than the rates in normal lung tissues (57.5%and 8.8%, respectively;P<0.05). The expressions of vasohibin-1 and MACC1 proteins were significantly correlated with the tumor grades, lymph node metastasis, and TNM stages (all P<0.05). Spearman correlation analysis indicated a positive correlation between vasohibin-1 expression and MACC1 expressions (P<0.001). Kaplan-Meier survival analysis showed that LSCC patients with a positive expression of vasohibin-1 had significantly shorter overall survival time than those negative for vasohibin-1;the overall survival time was also significantly shorter in patients positive for MACC1 than in those negative for MACC1 (both P<0.05). Multivariate COX regression analysis indicated that positive expressions of vasohibin-1 and MACC1 protein and TNM stage were independent prognostic factors of LSCC. Conclusion Aberrant expressions of vasohibin-1 and MACC1 may participate in the development and promote invasion and metastasis of LSCC. The combined detection of vasohibin-1 and MACC1 expression may provide important evidence for predicting the progression and prognosis of LSCC.关键词
肺鳞状细胞癌/vasohibin-1/MACC1/免疫组织化学/预后Key words
lung squamous cell carcinoma/vasohibin-1/MACC1/immunohistochemistry/prognosis引用本文复制引用
武世伍,王一超,慈红非,陶仪声..血管生成抑制蛋白1和结肠癌转移相关蛋白-1在肺鳞状细胞癌中的表达及其临床意义[J].南方医科大学学报,2017,37(7):952-956,5.基金项目
安徽省高等学校自然科学研究重点项目(KJ2015A269) （KJ2015A269）
安徽省自然科学基金(1708085MH230) （1708085MH230）
安徽省高等学校优秀青年人才重点支持计划(gxyqZD2016160) （gxyqZD2016160）
