南方医科大学学报2017，Vol.37Issue(8)：1014-1021,8.DOI:10.3969/j.issn.1673-4254.2017.08.03
高频超声心动图评价心梗小鼠左室整体功能和节段性室壁运动异常
High-frequency echocardiography for assessment of regional wall motion abnormality and cardiac function in mice with myocardial infarction
摘要
Abstract
Objective To evaluate the value of high-frequency echocardiography in assessing cardiac structure and function in a mouse model of myocardial infarction. Methods Twenty-five C57BL/6 mice were randomly divided into sham-operated group (n=10) and myocardial infarction model group (n=15) established by ligation of the left anterior descending artery. The cardiac structure, regional wall motion and cardiac function of mice were examined with pulsed wave Doppler (PWD), tissue Doppler imaging (TDI), EKV and M-mode echocardiography 3 days before and at 1 week after the operation. The histological changes and myocardial structure of the heart were observed at 1 week after the operation. Results High-frequency echocardiography and HE staining detected obvious myocardial infarction in the mice in the model group. Compared with the sham-operated mice, the mice with myocardial infarction showed significant left ventricular expansion, obvious thinning of the ventricular wall, and significantly decreased ventricular systolic function and diastolic function with regional wall motion abnormality and ventricular remodeling. Conclusions 2D-type echocardiography combined with M-mode, PWD, TDI and EKVTM for allows accurate and sensitive detection of the loci and severity of myocardial infarction to provide important evidence for clinical diagnosis and treatment of myocardial infarction.关键词
高频超声心动图/心梗模型/左室收缩功能/左室舒张功能/局部室壁运动指数Key words
high-frequency echocardiography/myocardial infarction/ventricular systolic function/ventricular diastolic function/regional ventricular wall motion index引用本文复制引用
王静,谭伟江,李想,张贵平,黄家园,陈小红,雷迁,杨丰华,黄韧..高频超声心动图评价心梗小鼠左室整体功能和节段性室壁运动异常[J].南方医科大学学报,2017,37(8):1014-1021,8.基金项目
国家自然科学基金(31672376) （31672376）
广东省科技专项(2016A020216019) （2016A020216019）
国家自然科学基金-青年科学基金(81500281) （81500281）
广东省实验动物重点实验(2013A061402001) Supported by National Natural Science Foundation of China (31672376). （2013A061402001）
