南方医科大学学报2017，Vol.37Issue(8)：1022-1027,6.DOI:10.3969/j.issn.1673-4254.2017.08.04
急性心肌梗死患者红细胞分布宽度与平均血小板体积的回归分析
Regression analysis of red cell distribution width and mean platelet volume in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate clinical implications of changes in red cell distribution width (RDW) and mean platelet volume (MPV) in patients with acute myocardial infarction. Methods A total of 127 patients (90 men and 37 women) were enrolled in this analysis, including 66 with acute myocardial infarction (AMI) and 61 with unstable angina (UA). The patients' baseline demographic and clinical data were compared between the two groups including age, hypertension, diabetes, smoking, BMI, blood biochemical profiles, cardiac functions and platelet and red blood cell parameters. The patients were further divided into subgroups according to the RDW 50% cumulative frequency, and the MPV, P-LCR, hsCRP, NT-proBNP, RBC, Dimer and MCV were compared. The correlations between platelet and erythrocyte test results were evaluated in both the AMI and UA patients. Regression analysis was performed to identify the factors affecting the RDW in the AMI group and a regression model was established. Results The platelet and red blood cell test results, P-LCR, MPV, and RDW differed significantly between AMI and UA groups (P<0.01 or 0.05). Correlation analysis showed a significant positive correlation between RDW and MPV in AMI group (r=0.34, P<0.01). Between the subgroups with different RDW 50% cumulative frequencies, MPV, P-LCR, hsCRP, D-Dimer, and NT-proBNP all differed significantly (P<0.05 or 0.01). In AMI group, with RDW as the dependent variable, we established a multivariate regression model of RDW=0.19MPV+10.83. Conclusion RDW and MPV are closely correlated in patients with AMI. In multiple regression analysis, MPV can explain the changes in RDW in patients with AMI.关键词
不稳定型心绞痛/急性心肌梗死/平均血小板体积/红细胞分布宽度/超敏C反应蛋白/D-二聚体Key words
unstable angina/acute myocardial infarction/mean platelet volume/red blood cell distribution width/high sensitive C reactive protein/D-Dimer引用本文复制引用
梁琦,雷新军,李红兵,殷艳蓉,任洁,范力宏,黄欣,袁祖贻..急性心肌梗死患者红细胞分布宽度与平均血小板体积的回归分析[J].南方医科大学学报,2017,37(8):1022-1027,6.基金项目
国家自然科学基金(81170276) Supported by National Natural Science Foundation of China (81170276). （81170276）
