法医学杂志2017，Vol.33Issue(3)：284-288,5.DOI:10.3969/j.issn.1004-5619.2017.03.015
窖蛋白与不明原因心源性猝死的相关性研究进展
Research Progress of the Correlation between Caveolin and Unexpected Sudden Cardiac Death
摘要
Abstract
D ue to the negative autopsy and w ithout cardiac structural abnorm alities, unexpected sudden cardiac death (U SC D ) is alw ays a tough issue for forensic pathological expertise. U SC D m ay be asso-ciated w ith parts of fatal arrhythm ic diseases. T hese arrhythm ic diseases m ay be caused by disorders of cardiac ion channels or channel-related proteins. C aveolin can com bine w ith m ultiple m yocardial ion channel proteins through its scaffolding regions and plays an im portant role in m aintaining the depolar-ization and repolarization of cardiac action potential. W hen the structure and function of caveolin are af-fected by gene m utations or abnorm al protein expression, the functions of the regulated ion channels are correspondingly im paired, w hich leads to the occurrence of m ultiple channelopathies, arrhythm ia or even sudden cardiac death. It is im portant to study the effects of caveolin on the functions of ion channels for exploring the m echanism s of m alignant arrhythm ia and sudden cardiac death.关键词
法医病理学/猝死,心脏/综述/窖蛋白/离子通道/心律失常,心性Key words
forensic pathology/death,sudden,cardiac/review/caveolin/ion channel/arrhythm ias,cardiac分类
社会科学引用本文复制引用
午方宇,罗斌,盖连磊,孔小平,郝博,黄二文,石河,盛立会,权力,刘水平..窖蛋白与不明原因心源性猝死的相关性研究进展[J].法医学杂志,2017,33(3):284-288,5.基金项目
国家自然科学基金资助项目(81671866,81430046) （81671866,81430046）
广东省自然科学基金自由申请项目(2016A030313223) （2016A030313223）
"十二五"国家重大科技攻关资助项目(2012BAK02B002) （2012BAK02B002）
上海市法医学重点实验室开放课题资助项目(2013KF1307) （2013KF1307）
