高等学校化学学报2017，Vol.38Issue(7)：1295-1302,8.DOI:10.7503/cjcu20160701
四氧化三铁纳米粒子表面接枝聚L-谷氨酸苄酯多孔微载体的构建和性能
Fabrication and Performance for Fe3O4 Nanoparticles Surface Grafted Poly(γ-benzyl-L-glutamate) Porous Microcarriers
摘要
Abstract
Ferroferric oxide/poly(γ-benzyl-L-glutamate)(PBLG) composite materials(Fe3O4-g-PBLG) was synthesized by initiating γ-benzyl-L-glutamate-N-carboxyanhydride(BLG-NCA) polymerization on the surface of amino-functionalized ferroferric oxide(Fe3O4) nanoparticles.Fe3O4-g-PBLG composites was confirmed by Fourier transform infrared and X-ray diffraction.Thermogravimetric(TGA) study showed that the grafting ratios of Fe3O4-g-PBLG were 66.36%,79.66%,and 89.52%,and grafting ratio of Fe3O4-g-PBLG composite could be controlled.The Fe3O4-g-PBLG with grafting ratio of 89.52% was used to fabricate magnetic Fe3O4-g-PBLG porous microcarriers.The porous microcarriers possessed suitable density(1.034 g/mL),porosity(92.57%),particle size(200-300 μm),pore size(40-50 μm) and water retention(370%-400%).Meanwhile,microcarriers exhibited superparamagnetism.Under the action of magnetic fields,the microcarriers can be arranged into any shape,showing significant advantages for the treatment of complex structure of the bone defects.These results showed that Fe3O4-g-PBLG porous microcarriers might be applied in bone tissue engineering.关键词
四氧化三铁/聚L-谷氨酸苄酯/多孔微载体/磁性能/骨组织工程Key words
Fe3O4/Poly(γ-benzyl-L-glutamate)(PBLG)/Porous microcarrier/Magnetic property/Bone tissue engineering分类
化学化工引用本文复制引用
徐盛华,夏鹏飞,张坤玺,高龙,尹静波..四氧化三铁纳米粒子表面接枝聚L-谷氨酸苄酯多孔微载体的构建和性能[J].高等学校化学学报,2017,38(7):1295-1302,8.基金项目
上海市科委基础研究重点项目(批准号:15JC1490400)和国家自然科学基金(批准号:51373094)资助.Supported by the Science and Technology Commission of Shanghai Municipality,China(No.15JC1490400) and the National Natural Science Foundation of China(No.51373094). （批准号:15JC1490400）
