口腔疾病防治2017，Vol.25Issue(7)：449-453,5.DOI:10.12016/j.issn.2096-1456.2017.07.009
慢性牙周炎合并高脂血症患者阿托伐他汀治疗期间血清脂蛋白磷脂酶A2和C反应蛋白水平变化
Changes of serum lipoprotein phospholipase A2 and CRP levels in patients with chronic periodontitis and hy-perlipidemia after atorvastatin treatment
摘要
Abstract
Objective To discuss the changes of serum lipoprotein phospholipase A2 (Lp - PLA2) and c-reactive protein (CRP) levels in atorvastat in treatment for the patients with periodontitis and hyperlipidemia. Methods 148 pa-tients with periodontitis and hyperlipidemia were involved, and divided into basic group (foundation treatment, 82 cases) and statin group (foundation treatment plus 20 mg atorvastatin treatment, 66 cases). 40 healthy cases from the medical center health personnel were selected as the healthy group. Attachment levels (AL), bleeding index (BI), serum total cho-lesterol (TC), triacylglycerol (TG), Lp-PLA2, and CRP levels were checked and compared before and after 6 months of treatment. Lp - PLA2 and CRP were checked by enzyme linked immunosorbent assay (ELISA), and their relationship were analyzed by the method of Pearson. Results When the disease group were compared with the healthy group, the statistics were as follows:AL(3.92 ± 0.51 mm vs 0.42 ± 0.06 mm), BI(2.81 ± 0.48 vs 0.34 ± 0.05), TC(5.27 ± 0.83 mmol/L vs 4.02 ± 0.62 mmol/L), TG(2.67 ± 0.41 mmol/L vs 0.93 ± 0.17 mmol/L), Lp-PLA2(243.57 ± 58.71μg/L vs 132.24 ± 34.27μg/L), CRP(9.72 ± 3.27μg/L vs 3.21 ± 0.87μg/L), and the statistics of disease group were significant-ly higher than the healthy group with a significant difference (P < 0.05). When Statin group was compared with basis group, the statistics were as follows: AL(3.70 ± 0.10 mmvs 3.78 ± 0.11 mm), BI(1.05 ± 0.28 vs 1.43 ± 0.32), TC (3.82 ± 0.67 mmol/L vs 4.51 ± 0.71 mmol/L), TG(1.30 ± 0.29 mmol/L vs 1.83 ± 0.34 mmol/L), Lp-PLA2(157.43 ± 40.18 μg/L vs 199.43 ± 47.24 μg/L), CRP(4.21 ± 3.02 μg/L vs 6.37 ± 3.28 μg/L), and the statistics of statin group were lower than that in basis group with a significant difference (P<0.05). Pearson analysis showed Lp-PLA2 and CRP levels were positively correlated (r=0.672, P<0.05). Conclusion It shows the changes of Lp-PLA2 and CRP level were related with the clinical conditions of periodontitis combined with hyperlipidemia, and atorvastatin therapy can ef-fectively reduce the body's blood lipid levels, and improve the treatment effects of periodontitis combined with hyperlip-idemia.关键词
牙周炎/高脂血症/阿托伐他汀/脂蛋白磷脂酶A2/C反应蛋白Key words
Periodontitis/Hyperlipidemia/Atorvastatin/lipoprotein phospholipase A2/C-reactive protein分类
医药卫生引用本文复制引用
王蔚璐,吴昌敬,夏长普,李朝晖..慢性牙周炎合并高脂血症患者阿托伐他汀治疗期间血清脂蛋白磷脂酶A2和C反应蛋白水平变化[J].口腔疾病防治,2017,25(7):449-453,5.基金项目
广东省中医药局建设中医药强省科研项目(20151071) （20151071）
