口腔疾病防治2017，Vol.25Issue(8)：498-500,3.DOI:10.12016/j.issn.2096-1456.2017.08.005
Beagle犬下颌重度牙槽嵴萎缩动物模型的建立
Construction of the animal model of mandibular severe alveolar bone atrophy in Beagle dogs
摘要
Abstract
Objective To establish an animal model that clinically conforms to the characteristics of severe alveo-lar ridge atrophy. Method Beagle dogs were used as experimental subjects. Bilateral fourth premolars and first molars in mandible were extracted. A horizontal groove was made on alveolar ridge which was 8 mm from the cemento-enamal junction of mandible third premolar and second molar. Rongeur was used to remove the alveolar bone above this groove and bone chisel was used to level the bone-free area. A box-shaped defect cavity of the size 25 mm × 8 mm was formed with sterile silicone prosthesis implanted. After careful suture we waited for the subjects to heal naturally. Eight weeks after operation, CBCT examination was performed. Results Eight weeks after bone remodeling the top of alveolar ridge of operation area appeared to be a circular arc. The average distance from the bottom of the ridge to inferior alveolar nerve canal was 2.5 mm. Conclusion This study successfully established the Beagle dog animal model for severe alve-olar ridge atrophy and laid the foundation for experiments on vertical bone augmentation.关键词
牙槽嵴萎缩/动物模型/垂直骨增量Key words
Alveolar bone atrophy/Animal model/Vertical bone augmentation分类
医药卫生引用本文复制引用
吕影涛,苏媛,马伟群,刘淑英,徐平平..Beagle犬下颌重度牙槽嵴萎缩动物模型的建立[J].口腔疾病防治,2017,25(8):498-500,3.基金项目
国家自然科学基金(81271187) （81271187）
广东省医学科学技术研究基金(A2015595) （A2015595）
