广东医学2017，Vol.38Issue(12)：1805-1808,4.
10%水合氯醛与2%戊巴比妥钠在建立术后疲劳综合征大鼠模型中的麻醉效果比较
Anesthesia effects of chloral hydrate and pentobarbital sodium on postoperative fatigue syndrome in rats
摘要
Abstract
Objective To compare the anesthesia effects of chloral hydrate (10%) and pentobarbital sodium (2%) on postoperative fatigue syndrome (POFS) model in rats.Methods Rat model of POFS were established by with enterectomy with anastomosis method.Twenty four adult male healthy rats were randomly divided into 2 groups, chloral hydrate group and pentobarbital sodium group.The durations of anesthesia induction and anesthesia duration, rat mortality, and success rate of the first dose of anesthesia were recorded.Anal temperature was measured at baseline, and 6 hours, 2 days, 4 days, 6 days and 8 days after operation.Morris water-maze test was carried out 2-7 dyas after operation.Meanwhile, grasping test was applied 1 day, 3 days, 5 days and 7 days after operation.Results There was no significant difference in mortality between the two groups.The induction time and deep anesthesia time in chloral hydrate (P<0.05), in which the rectal temperature was regained significantly faster.The maximum grips were significantly greater on Day 1, 3, 5 and 7 in chloral hydrate group (P<0.05), with significantly shorter escape latency and more platform crossing times (P<0.05).Conclusion Chloral hydrate can provide shorter induction time, satisfied duration, and higher the success rate of the first dose of anesthesia, suitable in constructing the POFS model.关键词
术后疲劳综合征/大鼠模型/水合氯醛/戊巴比妥钠Key words
postoperative fatigue syndrome/rat model/chloral hydrate/pentobarbital sodium引用本文复制引用
陈红燕,庞凤舜,陈经宝,冼敏玲,杨艳婷,胡琼,秦有..10%水合氯醛与2%戊巴比妥钠在建立术后疲劳综合征大鼠模型中的麻醉效果比较[J].广东医学,2017,38(12):1805-1808,4.基金项目
广东省科技计划项目(编号:2013B032500010) （编号:2013B032500010）
