Abstract
Objective To discuss the clinical curative effect of low-carbohydrate diet combined with liraglutide in type 2 diabetes mellitus patients with obesity.Methods 60 type 2 diabetes mellitus patients with obesity were randomly divided into two groups.Group A was given low-carbohydrate diet combined with liraglutide,and group B was given low-carbohydrate diet.Compared the changes of body weight (BW),body mass index (BMI),waist circumference,blood lipid (TC,TG,LDL,HDL),visceral fat,the fat rate,fasting blood glucose (FBG),postprandial 2 hours blood glucose (2hPBG),glycosylated hemoglobin (HbA1c),fasting insulin (FINS),insulin resistance index (HOMA-IR) of the two groups after treatment.Results After treatment,the body weight in group A reduced to (79.00±11.95)kg,the waist circumference reduced to (97.48±10.78)cm,BMI reduced to (27.72±3.10) kg/m2,TC,TG,LDL reduced to (4.42±0.86) mmol/L,(1.57±0.54) mmol/L,(3.12±0.61) mmol/L respectively,FBG,2hPBG reduced to (5.42±0.86) mmol/L,(7.26±0.84) mmol/L respectively,HbAlc reduced to (5.93±0.63)％,FINS reduced to (13.72±4.20) μ IU/ml;the body weight in group B reduced to (81.04±8.78)kg,the waist circumference reduced to (99.32±8.08)cm,BMI reduced to (28.84±2.35) kg/m2,TC,TG,LDL reduced to (4.74±0.72) mmol/L,(1.72±1.09) mmol/L,(3.25±0.84) mmol/L respectively,FBG,2hPBG reduced to (5.84±0.79)mmol/L,(7.99±1.04) mmol/L respectively,HbA1c reduced to (6.11±0.87)％,FINS reduced to (15.71±3.27) μ IU/ml;there were statistically significant differences in body weight,BMI,waist circumference,TC,TG,LDL,visceral fat,the fat rate,FBG,2hPBG,HbA1c,FINS,HOMA-IR between the two groups after treatment (P＜0.05),but HDL did not significantly improve after the intervention (P＞0.05).Conclusion Low-carbohydrate diet combined with liraglutide can significantly reduce body weight,improve obesity related indicators,reduce blood glucose,improve insulin resistance,and the effect is better than that of low-carbohydrate diet only.关键词
低碳水化合物饮食/利拉鲁肽/2型糖尿病/肥胖症Key words
Low-carbohydrate diet/Liraglutide/Type 2 diabetes mellitus/Obesity
