国际妇产科学杂志2017，Vol.44Issue(2)：125-128,4.
表观遗传学与卵巢癌耐药的关系研究
Study on the Relationship between Epigenetic and Drug Resistance in Ovarian Cancer
摘要
Abstract
Ovarian cancer mortality in the gynecology malignant tumor is the highest,the main clinical treatment is surgical resection and adjuvant chemotherapy,but easy to relapse after treatment.The research shows that the occurrence and development of tumor and drug resistance are related to epigenetics.The related researches also confirmed that epigenetics regulated the occurrence and development of ovarian cancer and drug resistance,such as DNA methylation,including RA SSF1A abnormal methylation and BRCA 1 abnormal methylation,histone modification including the methylation,acetylation,phosphorylation,ubiquitin,and so on,and miRNA genes.The epigenetics such as DNA methyltransferase inhibitors or histone deacetylase inhibitors can significantly improve the curative effect of ovarian cancer.The study of epigenetics and drug resistance in ovarian cancer are expected to provide new ideas and basis for clinical treatment of ovarian cancer.关键词
卵巢肿瘤/抗药性,肿瘤/后成说,遗传Key words
Ovarian neoplasms/Drug resistance,neoplasm/Epigenesis,genetic引用本文复制引用
陈家烨,费菁..表观遗传学与卵巢癌耐药的关系研究[J].国际妇产科学杂志,2017,44(2):125-128,4.基金项目
国家自然科学基金(81371881) （81371881）
浙江省自然科学基金(LY13H160018) （LY13H160018）
