结直肠癌患者BRAF,KRAS,NRAS和PIK3CA基因突变与其病理正的关系OACSTPCD
Relationship between BRAF, KRAS, NRAS, PIK3CA gene mutation and pathological characteristics in patients with colorectal cancer
目的:探讨265例结直肠癌患者BRAF,KRAS,NRAS和PIK3 CA基因突变及其病理特征关系.方法:选取2014年12月至2016年12月的265例结直肠癌患者肿瘤组织标本进行回顾性分析,采用PCR扩增-直接测序法检测BRAF基因(1 5外显子600密码子),KRAS基因(12,13,61密码子突变),NRAS(2号与3号外显子的12密码子、13密码子与61密码子常见的12个突变位点)及PIK3 CA(第9,20外显子)基因的突变状态,分析…查看全部>>
Objective:To study the relationship between BRAF,KRAS,NRAS and PIK3CA gene mutations and pathological characteristics in 265 patients with colorectal cancer.Methods:From December 2014 to December 2016,tumor tissues of 265 patients with colorectal carcinoma in our hospital were retrospectively analyzed,BRAF gene (exon 15 codon 600),KRAS (gene mutations of 12,13,61 codon),NRAS (2 and 3 in exon 12 codon 13,codon 61 codons and 12 common mutations) and PIK3CA (ex…查看全部>>
代云;郑国华;李青
溧阳市人民医院病理科,江苏溧阳213300溧阳市人民医院病理科,江苏溧阳213300常州市第一人民医院病理科,江苏常州213000
结直肠癌BRAFKRASNRASPIK3CA基因突变
colorectal cancerBRAFKRASNRASPIK3CAgene mutation
《国际病理科学与临床杂志》 2017 (5)
875-880,6
常州市卫生局重大项目(ZD2016018).This work was supported by the Changzhou Health Bureau Major Projects,China (ZD2016018).
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