临床与病理杂志2017，Vol.37Issue(5)：1047-1052,6.DOI:10.3978/j.issn.2095-6959.2017.05.030
信号转导和转录激活因子3与淋巴瘤关系及分子靶向治疗的研究进展
Research progress in signal transductions and activators of transcription 3 and molecular targeted therapy in lymphomas
摘要
Abstract
Signal transductions and activators of transcription 3 (STAT3) is widely expressed in cell lines and tissues,and regulates cell proliferation,differentiation,senescence,apoptosis and other physiological process.STAT3 is overexpressed and continuously activated in a variety of tumors,suggesting it plays a critical role in tumorgenesis and progression.Lymphoma is a kind of malignant hyperplastic diseases with heterogeneity and complicated pathological classification,which is originated in lymphatic hematopoietic system.The pathogenesis of lymphoma has not been completely elucidated.Recently,it was reported that STAT3 is abnormally expressed in various subtypes of lymphomas.This article summarizes the research progress of the role of STAT3 and the molecular targeted therapy in lymphomas.We expect to provide more strategies for the diagnosis and treatment oflymphomas by illuminating the relationship between STAT3 and lymphomas.关键词
信号转导和转录激活因子3/淋巴瘤/分子靶向治疗Key words
signal transductions and activators of transcription 3/lymphomas/molecular targeted therapy引用本文复制引用
高波,孙晶晶..信号转导和转录激活因子3与淋巴瘤关系及分子靶向治疗的研究进展[J].临床与病理杂志,2017,37(5):1047-1052,6.基金项目
国家自然科学基金(81660037),云南省高校病理学科技创新团队计划支持项目[云教科(2014)22号],云南省高校分子病理重点实验室建设项目[云教科(2016)37号].This work was supported by the National Natural Scientific Foundation (81660037),the Program for Innovative Research Team in University of Yunnan Province [YunJiao Ke (2014)22] and the Program for the Key Laboratory of Molecular Pathology in University of Yunnan Province [YunJiao Ke (2016)37],China. （81660037）
