广西医科大学学报2017，Vol.34Issue(7)：986-989,4.DOI:10.16190/j.cnki.45-1211/r.2017.07.008
不同药物预注射对胃镜检查中丙泊酚注射痛发生率及剂量的影响
Effects of different drugs pre-injection on the incidence of propofol injection pain and the dosage of propofol in gastroscopy
摘要
Abstract
Objective:To investigate the effect of different drugs pre-injection on the incidence of propofol injection pain and the dosage of propofol in gastroscopy.Methods:From October 2014 to November 2016,200 patients underwent gastroscopy in our hospital were randomly divided into control group (direct injection of propofol),observation group 1 (pre-injection of sufentanil),observation group 2 (pre-injection of lidocaine),and observation group 3 (pre injection of sufentanil and lidocaine),50 cases in each group.Before and after anesthesia,blood oxygen saturation (SpO2),heart rate (HR),mean arterial pressure (MAP),pain score,awake time,propofol total dose,adverse reactions incidence were compared.Results:There was no significant difference in SpO2,HR and MAP among four groups before anesthesia (P＜0.05).The HR and MAP at 5 min after anesthesia were lower than those before anesthesia in all groups,and the change was more significant in control group compared with observation group 1,observation group 2 and observation group 3.The pain scores among four groups were significant different (P＜0.05).The pain score of the observation group 3 was lower than those of the control group,observation group 1 and observation group 2 (P＜0.05).The differences in awake time,total propofol application dosage among four groups were also significant (P＜0.05),and those in observation group 1,2 and 3 were lower than that of the control group,and in observation group 3 was lower than those in observation group 1 and 2 (P＜0.05).There were no significant differences in the incidence of agitation,vomiting and nausea among groups (P＞0.05).Conclusion:Pretreatment with sufentanil and lidocaine in gastroscopy could significantly reduce the total dosage of propofol,decrease the propofol injection pain and shorten awake time without adverse effects on hemodynamics.关键词
胃镜检查/丙泊酚注射痛/丙泊酚剂量/舒芬太尼/利多卡因Key words
gastroscopy/propofol injection pain/propofol/sufentanil/lidocaine分类
医药卫生引用本文复制引用
许晓梦,曹金良,阮骆阳,梁大顺,杨作天..不同药物预注射对胃镜检查中丙泊酚注射痛发生率及剂量的影响[J].广西医科大学学报,2017,34(7):986-989,4.基金项目
广东省医学科学技术研究基金资助项目(No.C2016045) （No.C2016045）
