广西医科大学学报2017，Vol.34Issue(7)：1006-1009,4.DOI:10.16190/j.cnki.45-1211/r.2017.07.014
肝硬化患者肝功能分级与其肠道微生态的相关性研究
Correlation between liver function classification and intestinal microecology in patients with liver cirrhosis
陈瑶 1向正国 1李科军 1陈旭峰1
作者信息
- 1. 中国人民解放军第101医院消化内科,无锡 214000
- 折叠
摘要
Abstract
Objective:To explore the correlation between liver function and intestinal flora distribution and intestinal mucosal permeability in patients with liver cirrhosis.Methods:93 patients with liver cirrhosis treated in our hospital from March 2015 to December 2016 were selected and divided into group A (n=31),group B (n=38) and group C (n=24),according to the Child-Pugh classification criteria.40 healthy patients were selected as a control group.The distribution of intestinal flora,the levels of endotoxin and D-lactic acid in serum and the ratio of urinary lactulose/mannitol (L/M) were detected and compared among groups.The correlation between endotoxin level,D-lactate level,the ratio of urinary L/M and Child-Pugh classification were analyzed.Results:Patients with liver cirrhosis had larger number of enterobacter and enterococcus,but less Bacillus bifidus than the controls (P＜0.05),and these changes were the most obvious in group C.Spearman correlation analysis revealed that the Child-Pugh classification was positively related to the endotoxin level,D-lactate level and urinary L/M ratio (r=0.802,0.731,0.796;P＜0.05).Conclusion:Liver cirrhosis patients exhibited different degree of intestinal flora disorder and increase in in testinal mucosal permeability,and these changes were more significant with the increase of the grade of Child-Pugh.关键词
肝硬化/肠道菌群/肝功能/肠屏障/通透性/Child-Pugh分级Key words
liver cirrhosis/intestinal flora/liver function/intestinal barrier/permeability/Child-Pugh classification分类
医药卫生引用本文复制引用
陈瑶,向正国,李科军,陈旭峰..肝硬化患者肝功能分级与其肠道微生态的相关性研究[J].广西医科大学学报,2017,34(7):1006-1009,4.
