广西医科大学学报2017，Vol.34Issue(7)：1051-1054,4.DOI:10.16190/j.cnki.45-1211/r.2017.07.027
深部热疗联合同步放化疗治疗中晚期宫颈癌的疗效及机制研究
Effect of deep hyperthermia therapy combined with concurrent chemo-radiotherapy on advanced cervical cancer
曹蕾 1陈鑫 2加静 2郑明 2葛鹏2
作者信息
- 1. 陕西省西安医学院第二附属医院妇科,西安710038
- 2. 陕西省西安医学院第二附属医院胸外肿瘤科,西安710038
- 折叠
摘要
Abstract
Objective:To investigate the effect of deep hyperthermia combined with concurrent chemo-radiotherapy (CRT) on advanced cervical cancer and its influence on the expression of cell proliferation/apoptosis-related proteins.Methods:A total of 80 patients with advanced cervical cancer were randomly divided into a control group and an observation group,with 40 cases in each group.Patients in the control group received CRT treatment,while those in the observation group received CRT combined with deep hyperthermia therapy.The short-term effect,survival situation and the expression of vascular endothelial growth factor (VEGF),Bax,Bcl-2 and p53 in tumor tissue before and after treatment were compared between the two groups.Results:The response rate in the observation group was significantly higher than that in the control group (P＜0.05).After treatment,the expression of VEGF and Bax/Bcl-2 ratio in both groups were decreased,and the decrease in observation group was more significant (P＜0.05).The positive expression rate of Bax and p53 in both groups were markedly increased (P＜0.05).The Bax positive rate in the observation group was higher than that in the control group,while p53 was significantly lower (P＜0.05).The tumor-free survival rate within 1 year in the observation group was significantly higher than that in the control group (P＜0.05).There was no significant difference in the overall survival rate between the two groups (P＞0.05).Conclusion:The combined use of deep hyperthermia therapy and CRT was effective for the treatment of advanced cervical cancer.It could improve the short-term curative effect and elevate the tumor-free survival rate.The mechanism might be related to the inhibition of the expression of VEGF protein and p53 gene mutation in cancer tissue as well as up-regulating the Bax expression and reducing the Bax/Bcl-2 ratio.关键词
宫颈癌/深部热疗/同步放化疗/VEGF/细胞凋亡Key words
cervical cancer/deep hyperthermia therapy/concurrent chemo-radiotherapy/VEGF/cell apoptosis分类
医药卫生引用本文复制引用
曹蕾,陈鑫,加静,郑明,葛鹏..深部热疗联合同步放化疗治疗中晚期宫颈癌的疗效及机制研究[J].广西医科大学学报,2017,34(7):1051-1054,4.
