广西医学2017，Vol.39Issue(4)：440-443,4.DOI:10.11675/j.issn.0253-4304.2017.04.03
替比夫定与恩替卡韦对阿德福韦酯相关肾损害的慢性乙型肝炎患者肾功能改善效果比较及其影响因素
Efficacy comparison between telbivudine and entecavir on renal function recovery in chronic hepatitis B patients with adefovir dipivoxil-associated renal damage and its influence factors
摘要
Abstract
Objective To compare the clinical efficacy between telbivudine(LdT) and entecavir(ETV) on renal function recovery in chronic hepatitis B (CHB) patients with adefovir dipivoxil (ADV)-associated renal damage,and to investigate its influence factors.Methods A total of 41 CHB or liver cirrhosis due to hepatitis B patients with ADV-associated renal damage were divided into LdT group (n =21) and ETV group(n =20).The two groups were given LdT and ETV respectively after ADV withdrawal,and the treatment lasted for 24 weeks.The baseline and the variation of renal function after treatment were compared between the two groups,and the influence factors were analyzed.Results There was no significant difference in estimated glomerular filtration rate(eGFR) between the two groups at baseline(P ＞ 0.05),but the eGFRs were improved distinctly after 24 weeks of treatment in both groups compared to those before treatment,and the extent of eGFR improvement was more significant in LdT group than that in ETV group (all P ＜ 0.05).The multivariate logistic regression analysis showed that the baseline eGFR ＜60 ml · min-1 · 1.73 m-2 and LdT regimen were the influence factors of renal function recovery(all P ＜0.05).Conclusion LdT has more significant effects on renal function recovery in CHB patients with ADV-associated renal damage,especially for the patients whose baseline eGFRs are less than 60 ml · min-1 · 1.73 m-2.关键词
慢性乙型肝炎/肾功能/肾小球滤过率/阿德福韦酯/替比夫定/恩替卡韦/影响因素Key words
Chronic hepatitis B/Renal function/Estimated glomerular filtration rate/Adefovir dipivoxi/Telbivudine/Entecavir/Influence factor分类
医药卫生引用本文复制引用
刘宇,滕春玲,张萍,杜漫,王慧雯,李慧娇,郭莉,曹汴川,王荣明,吴育龙,江建宁..替比夫定与恩替卡韦对阿德福韦酯相关肾损害的慢性乙型肝炎患者肾功能改善效果比较及其影响因素[J].广西医学,2017,39(4):440-443,4.基金项目
广西自然科学基金(2014GXNSFDA118023) （2014GXNSFDA118023）
