广西医学2017，Vol.39Issue(7)：945-947,3.DOI:10.11675/j.issn.0253-4304.2017.07.04
合并不同慢性并发症的2型糖尿病患者血清胰岛素、糖化血红蛋白水平及其临床意义
Serum insulin and hemoglobin A1c levels of type 2 diabetes mellitus patients with different chronic complications and its clinical significance
摘要
Abstract
Objective To investigate the serum insulin(Ins) and hemoglobin A1c(HbA1c) levels of type 2 diabetes mellitus(T2DM) patients with different chronic complications and its clinical significance.Methods Sixty-two T2DM patients without any complications(control group) and 143 T2DM patients with different complications were enrolled,and the latter patients consisted of 41 patients complicated with diabetic nephropathy(DN group),65 patients with peripheral neuropathy(PN group) and 37 patients with multiple complications(multiple complications group).Oral glucose tolerance test(OGTT),Ins release test and HbA1c detection were performed in all patients.Results There were no significant differences in OGTT result or HbA1c level among the four groups(P>0.05).The fasting insulin(FIns) level of the DN group was higher than those in the 3 other groups(P<0.05),and the Fins level of the PN group was lower than those in the other 3 groups(P<0.05).The 0.5-and 1-hour postprandial insulin levels decreased in the order of DN group,control group,PN group and multiple complications group(P<0.05).The 2-hour postprandial insulin level decreased in the order of DN group,PN group,control group and multiple complications group(P<0.05).Conclusion Difference in serum Ins level exists in T2DM patients with different chronic complications,but no difference in their HbA1c level.It is important to detect serum Ins level for evaluating and treating chronic complications of T2DM patients.关键词
2型糖尿病/慢性并发症/胰岛素/糖化血红蛋白Key words
Type 2 diabetes mellitus/Chronic complications/Insulin/Hemoglobin A1c分类
医药卫生引用本文复制引用
黄朝任,黄荣哲,李绍持,徐波,何东昌,陆日秋..合并不同慢性并发症的2型糖尿病患者血清胰岛素、糖化血红蛋白水平及其临床意义[J].广西医学,2017,39(7):945-947,3.基金项目
国家高技术研究发展计划(863计划)(2014AA022304) （863计划）
