广西医学2017，Vol.39Issue(7)：952-954,3.DOI:10.11675/j.issn.0253-4304.2017.07.06
成人和儿童急性白血病常见融合基因表达的比较
Expression comparison of common fusion genes between adults and children with acute leukemia
摘要
Abstract
Objective To compare the expressions of common fusion genes between adults and children with acute leukemia.Methods The expressions of common fusion genes were detected in 279 patients with initial acute leukemia,including 159 adults and 120 children,by multiplex nested PCR.Then the positive rates of all fusion genes were compared between the adults and the children.Results The overall positive rate of leukemia fusion genes in the children with acute lymphoblastic leukemia(ALL) was higher than that in the adults with ALL[51.11%(46/90) vs.25.53%(24/94);P<0.05].The positive rates of TEL/acute myeloid leukemia(AML)1 and TLS/ERG fusion gene in the children were higher than those in the adults(P>0.05).The overall positive rate of leukemia fusion genes in the children with AML was higher than that in the adults with AML[53.33%(16/30) vs.26.15%(17/65);P<0.05],and the positive rate of AML1/ETO fusion gene in the children was higher than that in the adults(P>0.05).Conclusion There are some differences in the expressions of fusion genes between adults and children with acute leukemia,and the corresponding detection and interpretation of related fusion genes should be carried out to improve the quality of diagnosis and treatment.关键词
急性白血病/融合基因/巢式/聚合酶链反应Key words
Acute leukemia/Fusion genes/Nested/Polymerase chain reaction分类
医药卫生引用本文复制引用
唐艳萍,蔡政民,唐亚梅,苏程琳,谭晓玉,谢雨萱,利基林..成人和儿童急性白血病常见融合基因表达的比较[J].广西医学,2017,39(7):952-954,3.基金项目
广西科学研究与技术开发计划(桂科攻1298003-2-8) （桂科攻1298003-2-8）
