海南医学院学报2017，Vol.23Issue(11)：1488-1491,4.DOI:10.13210/j.cnki.jhmu.20170607.005
加倍剂量阿托伐他汀干预对2型糖尿病患者脂代谢、胰岛素抵抗及颈动脉粥样硬化的影响
Effect of doubling-dose atorvastatin intervention on lipid metabolism, insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus
摘要
Abstract
Objective: To study the effect of doubling-dose atorvastatin intervention on lipid metabolism, insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus.Methods: A total of 118 patients with type 2 diabetes mellitus treated in our hospital between May 2013 and December 2016 were collected, random number table was used to divide them into the single dose group (n=59) who received single-dose atorvastatin (20 mg/time, 1 times/d) therapy and the double dose group (n=59) who received doubling-dose atorvastatin (40 mg/time, 1 times/d) therapy, and both therapies lasted for 3 months.Serum levels of lipid metabolism indexes, insulin resistance indexes and carotid atherosclerosis-related indexes were compared between the two groups of patients before and after treatment.Results: Before treatment, differences in serum levels of lipid metabolism indexes, insulin resistance indexes and carotid atherosclerosis-related indexes were not statistically significant between two groups of patients (P>0.05).After treatment, serum lipid metabolism indexes TC, TG, FFA and LDL-C contents of observation group were lower than those of control group while HDL-C content was higher than that of control group;serum insulin resistance indexes INS and HOMA-IR levels were lower than those of control group while HOMA-β level was higher than that of control group;serum carotid atherosclerosis-related indexes visfatin, OPG, CysC and HMGB1 contents were lower than those of control group (P<0.05).Conclusions: Doubling-dose atorvastatin may be more effective in decreasing the hyperlipidemia and reducing the insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus.关键词
2型糖尿病/阿托伐他汀/脂代谢/胰岛素抵抗/颈动脉粥样硬化Key words
Type 2 diabetes mellitus/Atorvastatin/Lipid metabolism/Insulin resistance/Carotid atherosclerosis分类
医药卫生引用本文复制引用
马开颜,赵莉,陈苗利..加倍剂量阿托伐他汀干预对2型糖尿病患者脂代谢、胰岛素抵抗及颈动脉粥样硬化的影响[J].海南医学院学报,2017,23(11):1488-1491,4.基金项目
延安大学面向21世纪教改资助项目(YDJG04-10)This study was supported by foundation of teaching reform for the 21st century of Yanan university (grant No.YDJG04-10) （YDJG04-10）
