海南医学院学报2017，Vol.23Issue(11)：1537-1540,4.DOI:10.13210/j.cnki.jhmu.20170518.006
PECAM-1基因C373G位点多态性与子痫前期患者内皮损伤、胎盘病理损伤的相关性
Correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia
摘要
Abstract
Objective: To study the correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia.Methods: Pregnant women with preeclampsia and healthy pregnant women delivering in Obstetrics Department of Yibin Second People's Hospital between May 2014 and September 2016 were selected and enrolled in PE group and control group respectively.Peripheral blood was collected to determine PECAM-1 gene C373G polymorphism as well as the contents of endothelial injury molecules sEng, PAR-1, sFlt-1 and ET-1;placenta tissue was collected to determine the contents of pathological damage molecules Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3.Results: PECAM-1 gene C373G locus GC and GG genotype constituent ratio and allele G constituent ratio in peripheral blood of PE group were significantly higher than those of control group while CC genotype constituent ratio and allele C constituent ratio were significantly lower than those of control group.sFlt-1, sEng, PAR-1 and ET-1 contents in serum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PE group were significantly higher than those of control group;sFlt-1, sEng, PAR-1 and ET-1 contents in serum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PE patients with PECAM-1 gene C373G locus GC and GG genotypes were higher than those of PE patients with CC genotype.Conclusion: Increased allele G in PECAM-1 gene C373G loci is closely correlated with endothelial injury and placental pathological damage in patients with preeclampsia.关键词
子痫前期/血小板内皮细胞粘附分子-1/基因多态性/内皮损伤Key words
Preeclampsia/Platelet endothelial cell adhesion molecule-1/Gene polymorphism/Endothelial injury分类
医药卫生引用本文复制引用
严梅,伍班名,曾丽..PECAM-1基因C373G位点多态性与子痫前期患者内皮损伤、胎盘病理损伤的相关性[J].海南医学院学报,2017,23(11):1537-1540,4.基金项目
四川省卫生厅科学研究项目(101021)This study was supported by Sichuan provincial health department of scientific research (grant No.101021). （101021）
