解放军医药杂志2017，Vol.29Issue(4)：85-88,4.DOI:10.3969/j.issn.2095-140X.2017.04.022
唑来膦酸对骨质疏松患者骨痛、骨密度和血清骨代谢标志物的影响
Effects of Zoledronic Acid on Bone Pain, Bone Mineral Density and Serum Bone Metabolism Markers of Osteoporosis Patients
摘要
Abstract
Objective To investigate effects of Zoledronic Acid on bone pain,bone mineral density (BMD) and bone metabolic markers of patients with osteoporosis (OP).Methods A total of 84 OP patients admitted during June 2013 to July 2014 were divided into Zoledronic Acid group and Alendronate Sodium group (n =42 for each group) according to different treatment methods.Degrees of bone pain,BMD and serum changes of bone metabolic markers were recorded and compared before and after treatment in two groups.Results Effective rate and the total effective rate in Zoledronic Acid group were significantly higher than those in Alendronate Sodium group (P ＜ 0.05),BMD values of lumbar vertebra normotopia (L2~) and right femoral neck after treatment for 6 months and 12 months were significantly higher than those before treatment in two groups,and the values in Zoledronic Acid group after treatment for 12 months were significantly higher than those in Alendronate Sodium group (P ＜ 0.05).Levels of specific alkaline phosphatase and beta collagen fragment were significantly lower,while calcitonin level was significantly higher after treatment in Zoledronic Acid group than those before treatment and in Alendronate Sodium group (P ＜ 0.05).There was no significant differencein incidence rate of adverse reactions between the two groups (P ＞ 0.05).Conclusion Zoledronic Acid can effectively relieve pain symptoms of patients with OP,improve serum indexes of bone metabolism and increase level of bone mineral density.关键词
骨质疏松/唑来膦酸/血清骨代谢标志物/骨密度Key words
Osteoporosis/Zoledronic acid/Serum markers of bone metabolism/Bone density分类
医药卫生引用本文复制引用
杨志新,杨磊,钱阳晶..唑来膦酸对骨质疏松患者骨痛、骨密度和血清骨代谢标志物的影响[J].解放军医药杂志,2017,29(4):85-88,4.基金项目
湖北省自然科学基金资助项目(2013CFA065) （2013CFA065）
